نتایج جستجو برای: inos protein

تعداد نتایج: 1236459  

2016
Salome' V Ibba Mohamed A Ghonim Kusma Pyakurel Matthew R Lammi Anil Mishra A Hamid Boulares

Although expression of inducible NO synthase (iNOS) in the lungs of asthmatics and associated nitrosative damage are established, iNOS failed as a therapeutic target for blocking airway hyperresponsiveness (AHR) and inflammation in asthmatics. This dichotomy calls for better strategies with which the enzyme is adequately targeted. Here, we confirm iNOS expression in the asthmatic lung with conc...

Journal: :Journal of immunology 2013
Divya Purushothaman Nimi Marcel Megha Garg Rasika Venkataraman Apurva Sarin

Lineage-committed T effectors generated in response to Ag during the inflammatory phase are destined to die during termination of the immune response. We present evidence to suggest that molecular signatures of lineage commitment are reflected in apoptotic cascades activated in CD4(+) T effectors. Exemplifying this, ablation of inducible NO synthase (iNOS) protected effector-memory T (TEM) cell...

Journal: :American journal of respiratory and critical care medicine 2005
Xinqi Peng Raja-Elie E Abdulnour Saad Sammani Shwu-Fan Ma Eugenia J Han Emile J Hasan Rubin Tuder Joe G N Garcia Paul M Hassoun

RATIONALE Inducible nitric oxide synthase (iNOS) has been implicated in the development of acute lung injury. Recent studies indicate a role for mechanical stress in iNOS and endothelial NOS (eNOS) regulation. OBJECTIVES This study investigated changes in lung NOS expression and activity in a mouse model of ventilator-induced lung injury. METHODS C57BL/6J (wild-type [WT]) and iNOS-deficient...

Journal: :American journal of physiology. Cell physiology 2011
Suxin Luo Tingting Wang Honghua Qin Han Lei Yong Xia

Inducible nitric oxide (NO) synthase (iNOS) plays an important role in cell injury and host defense. While undetectable in normal tissues, iNOS expression is induced by endotoxins and inflammatory cytokines primarily via the IκB kinase/nuclear factor-κB (IKK-NF-κB) and Janus kinase (JAK)-signal transducers and activators of transcription 1 (STAT1) pathways. Our previous studies found that heat ...

Journal: :American journal of physiology. Cell physiology 2013
So-Young Hwang Ji-Sun Hwang Song-Yi Kim Inn-Oc Han

O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT), which catalyzes the addition of a single β-N-GlcNAc unit to target proteins, has been shown to act as a transcriptional regulator. In the current study, we discovered that OGT exerted inhibitory effects on the LPS-driven activation of NF-κB and inducible nitric oxide synthase (iNOS). In response to LPS, OGT exhibited an increased intera...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2001
M J Morin S M Karr R A Faris P A Gruppuso

Inducible nitric oxide synthase (iNOS) may be a key mediator of intestinal injury, which varies with developmental age. One member of the mitogen-activated protein kinase (MAPK) family, p38, is involved in the lipopolysaccharide (LPS)-mediated iNOS induction. The involvement of p38 MAPK in basal and LPS-induced iNOS expression was examined in the rat intestine at two developmental ages. Neonata...

Journal: :International journal of clinical and experimental pathology 2013
Huai Huang Lei Xue Xu Zhang Qibiao Weng Huiqiang Chen Jing Gu Shuilin Ye Xiaodong Chen Wei Zhang Huangyi Liao

OBJECTIVE To investigate the effect of hyperbaric oxygen therapy (HBOT) on the iNOS mRNA-iNOS-NO signaling pathway and neurofunction protected in a rat spinal cord injury model. METHODS A total of 36 Sprague-Dawley rats were randomly divided into 3 groups: control group (n=12), SCI group (n=12) and SCI + HBOT group (n=12). SCI + HBOT group In the SCI group and SCI + HBOT groups, SCI was perfo...

Journal: :Journal of immunology 2006
Marc Bergeron Martin Olivier

Although the effects of activated macrophages (Muphi) on the intracellular parasite Trypanosoma cruzi are well documented, little is known about how host-Muphi functions are affected by this pathogen before activation. This study is aimed at assessing the capacity of T. cruzi infection to modulate J77.4 murine Muphi NO generation following IFN-gamma stimulation, and identifying mechanisms regul...

Journal: :Diabetes 2005
Masaki Fujimoto Nobuyuki Shimizu Kaiko Kunii J A Jeevendra Martyn Kohjiro Ueki Masao Kaneki

Chronic inflammation has been postulated to play an important role in the pathogenesis of insulin resistance. Inducible nitric oxide synthase (iNOS) has been implicated in many human diseases associated with inflammation. iNOS deficiency was shown to prevent high-fat diet-induced insulin resistance in skeletal muscle but not in the liver. A role for iNOS in fasting hyperglycemia and hepatic ins...

Journal: :JPEN. Journal of parenteral and enteral nutrition 2007
Kosuke Matsui Yusai Kawaguchi Takashi Ozaki Katsuji Tokuhara Hironori Tanaka Masaki Kaibori Yoichi Matsui Yasuo Kamiyama Koji Wakame Takehito Miura Mikio Nishizawa Tadayoshi Okumura

BACKGROUND Active hexose correlated compound (AHCC) is a "complex compound" containing polysaccharides. AHCC has been reported to improve the prognosis of postoperative hepatocellular carcinoma patients. However, the molecular mechanism of this improvement is not fully understood. In the diseased liver, nitric oxide (NO) generated by inducible nitric oxide synthase (iNOS) is considered to be a ...

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