Regional dilation (expansion) of newly infarcted myocardium has been associated with increased mortality. To study this entity further, and to define the relationship of expansion to infarct morphology, infarcts were created in 44 open-chest dogs by a coronary ligation and coronary embolization method. Twenty-one transmural and 18 nontrangmural infarcta of 1 to 11 days of age were studied. Infa...

OBJECTIVES We hypothesized that infarct transmurality assessed with late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) predicts arrhythmic events in patients with chronic myocardial infarction. BACKGROUND Patients with decreased left ventricular function due to chronic myocardial infarction are at increased risk for life-threatening arrhythmias related to infarcted tissue. LGE-C...

BACKGROUND AND PURPOSE We investigated to what extent excitotoxicity and metabolic changes in the peri-infarct region of patients with malignant hemispheric stroke are associated with delayed infarct progression. METHODS In 18 patients with malignant hemispheric stroke, 2 microdialysis probes were implanted within the peri-infarct tissue at a distance of 5 and 15 mm to the infarct. Precise pr...

BACKGROUND Following acute myocardial infarction (AMI), microvascular obstruction (MO) and intramyocardial hemorrhage (IMH) adversely affect left ventricular remodeling and prognosis independently of infarct size. Whether this is due to infarct zone remodeling, changes in remote myocardium or other factors is unknown. We investigated the role of MO and IMH in recovery of contractility in infarc...

Introduction. Increased resistance of the heart to ischemia/reperfusion (I/R) is an urgent aim physiology, pharmacology, and cardiac surgery, since I/R injury often cause cardiogenic shock subsequent death patients in postoperative period. Materials methods. The study was carried out male rats which were subjected coronary artery occlusion (45 min) reperfusion (2 h). Before occlusion, early hyp...

Factors Affecting Left Ventricular Remodeling Early coronary artery reperfusion is clearly the most important therapy for acute ST segment elevation myocardial infarcts. Early reperfusion reduces myocardial infarct size and in so doing helps to prevent or minimize deleterious consequences of a large myocardial infarction, including infarct expansion (thinning and dilation of the infarct), subse...

Patients suffering an acute myocardial infarction routinely receive morphine and NSAIDs alone or in combination. However, the importance of the dose, timing or the combined administration of both on infarct size reduction has not been assessed. Additionally, it is not known if morphine or NSAIDs require 12-lipoxygenase (12-LO) to mediate infarct size reduction as previously found for ischemic p...

Left ventricular (LV) remodeling following myocardial infarction (MI) is the result of complex interactions between various factors, including presence or absence of early revascularization. The impact of early revascularization on the relationship between infarct tissue characteristics and LV remodeling is incompletely known. Therefore, we investigated in patients with versus without successfu...

BACKGROUND AND PURPOSE Rapid occlusion of the middle cerebral artery above the rhinal fissure produces a large ischemic infarct in hypertensive rats, but this occlusion results in a minimal lesion in young normotensive rats. Our purpose was to attenuate rising blood pressure in young stroke-prone spontaneously hypertensive rats with hydralazine before the occlusion to determine if the gross inf...

Introduction: TRPV1 is a non-selective cation channel with high permeability to calcium ions, and is also involved in the development of neurogenic and inflammatory pain. The increase in intracellular calcium plays a role in worsening of stroke. In the present study we investigated the effect of (AMG9810) TRPV1 receptor antagonist on stroke outcome in the permanent middle cerebral artery occlus...