Primary dermal and eye irritation tests of hydrophobically modified hydroxypropyl methylcellulose (HM-HPMC, hydroxypropyl methylcellulose modified with stearylglycidylether), a new cellulose derivative used as a thickener for topical pharmaceuticals and cosmetics, were conducted in rabbits. A dispersion of HM-HPMC (3%) was applied to intact and abraded skins and reactions were observed. A very ...

In this comprehensive review, we report on the preparation of graft-copolymers of cellulose and cellulose derivatives using atom transfer radical polymerization (ATRP) under homogeneous conditions. The review is divided into four sections according to the cellulosic material that is graft-copolymerised; (i) cellulose, (ii) ethyl cellulose, (iii) hydroxypropyl cellulose and (iv) other cellulose ...

The aim of the present work was to develop novel hydrogels for delivering sertaconazole based on cyclodextrins and various biocompatible polysaccharides. Sertaconazole is an antifungal agent very effective for treatment of Candida albicans infections. However its poor aqueous solubility is still a challenging issue for developing suitable formulations. Complexation with cyclodextrins is a very ...

Chemical functionalization of cellulose aims to adjust the properties of macromolecule for different purposes, particularly, as a chemical feedstock for production of cellulose derivatives for a variety of applications. The conventional sources of cellulose include cotton linters and wood pulp which now-a-days are discouraged on account of the cost of the former and environment conservative reg...

The objective of this project was to improve the solubility poorly water soluble drugs, namely cefuroxime axetil by formulating solid dispersions with hydrophilic polymer. Hydroxypropyl methyl cellulose (HPMC), polyvinyl pyrrolidine (PVP) and polyethylene glycol (PEG) were used as polymeric carriers for preparation dispersion. Solid prepared solvent extraction method. Interaction effect HPMC, P...

In majority of individuals blood pressure rises in the early morning hours, which lead to serious cardiovascular complications. Formulation of pulsatile system makes it possible to deliver drug at definite period of time when symptoms of the disease condition are most critical. The purpose of the present work was to develop pulsatile release tablet of losartan potassium for chronotherapy in hyp...

Lamotrigine is a substituted asymmetric triazine. It is a white to pale cream-coloured powder. It is slightly soluble in ethanol and chloroform, and very slightly soluble in water. The pKa of lamotrigine at 25°C is 5.7. Each Lamictal Dispersible/Chewable tablet also contains calcium carbonate, hydroxypropyl cellulose, aluminium magnesium silicate, sodium starch glycollate, povidone, saccharin s...

Structurally Colored Cholesteric Phases of Cellulose In article number 2205506, Ozge Akbulut, Ahu Gümrah Dumanli, and co-workers describe a 3D printing the hydroxypropyl cellulose (HPC) filaments with two-order hierarchical structures similar to multi-hierarchical arrangement found in nature such as Morpho butterflies. this arrangement, helicoids formed cholesteric phase HPC give rise blue colo...