Abstract Erythrochelin, a hydroxamate-type siderophore produced by Saccharopolyspora erythraea, is synthesized for the first time. A key building block of erythrochelin containing the 2,5-diketopiperazine ring is prepared by intramolecular cyclization of the corresponding dipeptide precursor derived from two kinds of protected δ-N-hydroxy-L-ornithines. Consecutive condensation of the building b...

Hydroxamic acids, a group of naturally occurring and synthetic weak organic acids of general formula RC(=O)N(R')OH, are widespread in the tissues of plants, in metabolites of bacteria and fungi, including complex compounds. Hydroxamic acids and their derivatives fulfill a variety of important roles in biology and medicine; here we provide a comprehensive brief review of the most basic medicinal...

Acyl CoA derivatives of a number of cinnamic and benzoic acids have been synthesised via the appropriate acyl phenyl thiol esters. The reaction has potential application in the preparation of acyl CoA derivatives of radiolabelled aromatic carboxylic acids. UV absorption spectra have been determined for the CoA thiol esters following their purification by gel permeation chromato­ graphy. By comp...