نتایج جستجو برای: hydrochloride heroin

تعداد نتایج: 50020  

Journal: :Archives of general psychiatry 2001
Y I Hser V Hoffman C E Grella M D Anglin

BACKGROUND This study examined longitudinal patterns of heroin use, other substance use, health, mental health, employment, criminal involvement, and mortality among heroin addicts. METHODS The sample was composed of 581 male heroin addicts admitted to the California Civil Addict Program (CAP) during the years 1962 through 1964; CAP was a compulsory drug treatment program for heroin-dependent...

Journal: :The American journal on addictions 2006
Shu-Chuan Chiang Shaw-Ji Chen Hsiao-Ju Sun Hung-Yu Chan Wei J Chen

This study examines differences in psychosocial characteristics, substance use history, and psychiatric comorbidity in relation to heroin use among youths aged 15 to 22 incarcerated in 2003 for illicit drug use in northern Taiwan. Factors associated with heroin use included experiences of child abuse, having friends with illicit drug use, poor school attendance, polydrug use, and early age of d...

2017
Peng-Wei Wang Huang-Chi Lin Yi-Hsin Connie Yang Chih-Yao Hsu Kuan-Sheng Chung Hung-Chi Wu Cheng-Fang Yen

Introduction Both heroin use and depression are significant health problems. Methadone maintenance treatment (MMT) can be of great benefit to heroin users. However, changes in the level of depression in heroin users during MMT are not clear. Gender and age are also important factors in the development of depression, and whether gender and age moderate changes in depression in heroin users durin...

2014
Ben J Watson Lindsay G Taylor Alastair G Reid Sue J Wilson Paul R Stokes David J Brooks James F Myers Federico E Turkheimer David J Nutt Anne R Lingford-Hughes

The rewarding properties of some abused drugs are thought to reside in their ability to increase striatal dopamine levels. Similar increases have been shown in response to expectation of a positive drug effect. The actions of opioid drugs on striatal dopamine release are less well characterized. We examined whether heroin and the expectation of heroin reward increases striatal dopamine levels i...

Journal: :Genetic testing and molecular biomarkers 2012
Chao Meng Jie Lan Youxin Wang Manshu Song Xuan Gao Longjin Ran Sim Moira Wei Wang

AIM The study aims at evaluating the association between brain-derived neurotrophic factor (BDNF) gene polymorphisms and heroin-dependent patients in the Chinese population. Three polymorphisms of the BDNF-gene (rs10835210, rs16917234, and rs6265) in 486 heroin-dependent patients and in 226 healthy controls were genotyped for analyzing the association of these polymorphisms with age of onset of...

Journal: :The Journal of pharmacology and experimental therapeutics 2004
Donna M Platt James K Rowlett Sari Izenwasser Roger D Spealman

3-O-Methylnaltrexone (3-MNTX), a putative antagonist of morphine-6-beta-d-glucuronide (M6G) receptors, has been reported to block the behavioral effects of heroin at doses that do not block those of morphine, suggesting that M6G receptors may play a unique role in the addictive properties of heroin. This study investigated the effects of 3-MNTX in monkeys trained to discriminate i.v. heroin fro...

Journal: :Genetics and molecular research : GMR 2015
J H Liu H J Zhong J Dang L Peng Y S Zhu

Previous studies suggested that dopamine receptors may be associated with drug dependence and impulsive behavior. In this study, we examined whether dopamine receptor D1 (DRD1) is associated with heroin dependence and the impulsive behavior in patients with heroin dependence. The participants included 367 patients with heroin dependence and 372 healthy controls from a Chinese Han population. We...

2013
Jenny Chalmers

One of the core objectives of supply-side drug law enforcement is to reduce drug use by raising the cost of buying drugs. The effectiveness of this strategy depends on how illicit drug users respond to the rise in costs. The aim of the current study was to estimate how methamphetamine users would respond to changes in the prices of methamphetamine and heroin, using hypothetical drug purchasing ...

Journal: :The Journal of pharmacology and experimental therapeutics 2010
Donna M Platt James K Rowlett Roger D Spealman

Many polydrug abusers combine cocaine with heroin in the form of a "speedball." This study investigated the discriminative stimulus (DS) effects of speedballs in rhesus monkeys trained to discriminate either intravenous cocaine or intravenous heroin from vehicle. Initial substitution tests revealed an asymmetry in the generalization profile of dopamine and opioid agonists such that mu agonists ...

Journal: :Pharmacological reports : PR 2005
Wojciech Solecki Tomasz Krówka Małgorzata Filip Ryszard Przewłocki

The present study was designed to investigate the involvement of opioidergic component as well as to study GABAergic mechanisms in the expression of heroin discrimination. Male Wistar rats were trained to discriminate heroin (0.5 mg/kg, i.p.) from saline (i.p.) in a two-choice water reinforced fixed ratio (FR) 20 drug discrimination paradigm. In substitution tests, heroin (0.0625-0.5 mg/kg) and...

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