نتایج جستجو برای: histone deacetylase inhibitor

تعداد نتایج: 249468  

2006
Steven D. Gore Stephen Baylin Elizabeth Sugar Hetty Carraway Carole B. Miller Michael Carducci Michael Grever Oliver Galm Tianna Dauses Judith E. Karp Michelle A. Rudek Ming Zhao Douglas Smith Jasper Manning Anchalee Jiemjit Abbie Mays James Zwiebel Anthony Murgo Li-Jun Weng James G. Herman

Optimal reexpression of most genes silenced through promoter methylation requires the sequential application of DNA methyltransferase inhibitors followed by histone deacetylase inhibitors in tumor cell cultures. Patients with myelodysplastic syndrome or acute myeloid leukemia (AML) were treated with the methyltransferase inhibitor 5-azacitidine (aza-CR) followed by the histone deacetylase inhib...

Journal: :Cancer research 2006
Steven D Gore Stephen Baylin Elizabeth Sugar Hetty Carraway Carole B Miller Michael Carducci Michael Grever Oliver Galm Tianna Dauses Judith E Karp Michelle A Rudek Ming Zhao B Douglas Smith Jasper Manning Anchalee Jiemjit George Dover Abbie Mays James Zwiebel Anthony Murgo Li-Jun Weng James G Herman

Optimal reexpression of most genes silenced through promoter methylation requires the sequential application of DNA methyltransferase inhibitors followed by histone deacetylase inhibitors in tumor cell cultures. Patients with myelodysplastic syndrome or acute myeloid leukemia (AML) were treated with the methyltransferase inhibitor 5-azacitidine (aza-CR) followed by the histone deacetylase inhib...

Journal: :Neuro-oncology 2022

Abstract Developing and evaluating potential radiosensitisers to enhance therapeutic efficacy are urgently needed due the lack of efficient chemotherapy for meningioma. Histone deacetylase (HDACs) expression is generally increased in many cancer types regulate numerous proteins involved tumorigenesis. Targeting HDAC using inhibitor (HDACi) represent promising that affect various biological proc...

Journal: :Cancer research 2004
David Z Qian Xiaofei Wang Sushant K Kachhap Yukihiko Kato Yongfeng Wei Lu Zhang Peter Atadja Roberto Pili

Chromatin remodeling agents such as histone deacetylase inhibitors have been shown to modulate gene expression in tumor cells and inhibit tumor growth and angiogenesis. Vascular endothelial growth factor (VEGF) and VEGF receptors represent critical molecular targets for antiangiogenesis therapy. In this study, we investigated the biological effect of the histone deacetylase inhibitor NVP-LAQ824...

Journal: :Bioorganic & medicinal chemistry 2006
Mohammed P I Bhuiyan Tamaki Kato Tatsuo Okauchi Norikazu Nishino Satoko Maeda Tomonori G Nishino Minoru Yoshida

A series of chlamydocin analogs with various carbonyl functionalities were designed and synthesized as histone deacetylase (HDAC) inhibitors. Chlamydocin is a cyclic tetrapeptide containing an epoxyketone surrogate in the side chain which makes it irreversible inhibitor of HDACs, whereas apicidins are a class of cyclic tetrapeptides that contain an ethylketone moiety as zinc ligand. We replaced...

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