Anabolic androgenic steroids (AAS) have been abused for decades by both professional and amateur athletes in order to improve physical performance or muscle mass. AAS abuse can cause adverse effects, among which are hepatotoxic effects. These effects include cholestatic icterus and possibly peliosis hepatis and hepatocellular carcinoma or adenoma. In particular, 17α-alkylated AAS appear to be h...

Blood samples of animals from groups I and II were taken for liver function tests by cardiac puncture under ether anaesthesia Hepatotoxicity due to antitubercular drugs is found to be mediated through oxidative stress and free radical damage to hepatocytes (1, 2, 3). The antioxidants α-tocopherol and selenium are known exert beneficial effect in antitubercular drugs induced hepatotoxicity (4, 5...

The hepatotoxic effect of 1,1 bis (p-chlorophenyl) 2,2,2 trichloroethane (DDT) treatment for 10 consecutive days has been examined in Wistar rats. DDT exposure increased relative liver weight, dose dependently, with a marked decrease of glycogen content and profound histological changes including cytoplasmic vacuolization, signs of necrosis and nuclear enlargement. The hepatomegaly induced by D...

Two or three decades ago chronic liver injury due to drugs was scarcely recognized. Today a wide range of diseases, previously thought to be due to 'natural' causes, is attributed to therapy, although final proof of the cause is often difficult or impossible to achieve. In addition, new drugs have been produced which have subsequently been shown to have hepatotoxic effects. These may only be ma...

This study evaluated the protective effects of Noni fruit juice on acute liver injury induced by carbon tetrachloride (CCl(4)) in female Sprague-Dawley (SD) rats. Liver damage (micro-centrilobular necrosis) was observed in animals pretreated with 20% placebo (drinking water) + CCl(4). However, pretreatment with 20% Noni juice in drinking water + CCl(4) resulted in markedly decreased hepatotoxic...

Objective: To investigate the hepatotoxic effects of halofantrine in guinea pigs. Material and Methods: Halofantrine (30-105 mg/kg) was administered orally to three groups of guinea pigs thrice a week for 4 weeks. One group of animals which received distilled water served as control. The relative weight of the liver was measured. The biochemical parameters like alanine transaminase (ALT), aspar...