The switch from fetal to adult hemoglobin is incomplete; the residual fetal hemoglobin in adults is restricted to a subset of erythrocytes called F cells. F-cell levels are influenced by a sequence variant (C-->T) at position -158 upstream of the gamma-globin gene, termed the XmnI-Ggamma polymorphism. How the Ggamma-158 C-->T variant influences the expression of the Ggamma-globin gene is unknow...

Studies of fetal hemoglobin and bone marrow ultrastructure were performed on a patient with a recently described syndrome consisting of lymphosarcoma, short stature, defective cellular Immunity, hypogammaglobulinemia, and mosaicism for a marker chromosome. Abnormalities of the erythroid cells, including multinucleated erythroblasts, nuclear bodies, megaloblasts, and frayed cytoplasm, were seen ...

The dissociation of the extracellular hemoglobin of the earthworm Lumbricus terrestris was investigated. At neutral pH, its sz00,~ = 58.9 f 0.2 S and D:o,w = 1.61 f 0.05 X 1O-7 cm2 s-l corresponded to a molecular weight of 3.23 f 0.18 x 106. A minimum molecular weight of 24,000 per heme group was determined from the iron and heme contents, 0.221 f 0.011 weight % and 2.78 =k 0.14 weight %, respe...

A B S T R A C T The extent of dissociation of various hemoglobins into subunits was estimated from their elution volumes (V.) on G-100 Sephadex. Under the same controlled conditions carboxyhemoglobins A, A3 (A,), F, S, and C all had the same elution volumes. The carboxy and cyanmet derivatives of hemoglobin Kansas (a variant with very low oxygen affinity) had a relatively high Ve, indicating a ...

background: national surveys in india have documented an increasing number of adolescent girls suffering from anemia. efforts to build iron stores in adolescent girls will help them improve their prepregnancy hemoglobin level. to assess the effectiveness of school-based supervised weekly, bi–weekly, and daily regimen of iron folic tablets in the treatment of anemia among adolescent girls. metho...

It has been known for many years that high levels of fetal hemoglobin (Hb F) have an important clinical benefit in patients with sickle cell anemia (SCA). This knowledge was initially based on the observation that populations of Indian and Arabian SCA patients with high Hb F levels have a milder clinical form of the disease.1 Later on, epidemiological studies demonstrated that patients with Hb ...