BACKGROUND Methicillin-resistant Staphylococcus aureus is a leading cause of death in patients undergoing hemodialysis. However, controversy exists about the optimal dose of vancomycin that will yield the recommended pre-hemodialysis serum concentration of 15-20 mg/L. OBJECTIVE To develop a data-driven model to optimize the accuracy of maintenance dosing of vancomycin for patients undergoing ...

One hundred and seventy-four rats received a standardized 0.4-ml injection into the left infraorbital nerve and all solutions contained lignocaine 0.25 g dl-1. In groups 1-4, the solutions were isoosmotic and contained, besides sodium chloride, potassium chloride 0 or 4 mmol litre-1 and glucose 0 or 20 mmol litre-1 (0 or 360 g dl-1). For groups 5-8, the solutions were hypoosmotic, containing so...

AIM To identify independent predictors of hemodialysis treatment outcome among major cardiovascular risk factors and pre-existent cardiovascular diseases in maintenance hemodialysis patients with the end-stage renal disease. METHODS A total of 144 prevalent patients on maintenance hemodialysis at Rijeka University Hospital between 1998 and 2003 were included in the prospective clinical study....

INTRODUCTION Renal replacement therapy is the treatment of end-stage chronic kidney disease and can be performed through dialysis catheters, arteriovenous fistulas/grafts, and peritoneal dialysis. Patients are usually immunocompromised and exposed to invasive procedures, leading to high rates of infection and increased mortality. OBJECTIVES To compare the prevalence of infection and related d...

The Frequent Hemodialysis Network Daily Trial randomized 245 patients to receive six (frequent) or three (conventional) in-center hemodialysis sessions per week for 12 months. As reported previously, frequent in-center hemodialysis yielded favorable effects on the coprimary composite outcomes of death or change in left ventricular mass and death or change in self-reported physical health. Here,...

Introduction: Food intake during hemodialysis increases the risk of problems such as hypotension, nausea, and vomiting in patients undergoing hemodialysis. This study aimed to determine the effect of mealtime during dialysis on the patients' complications. Methods: This is a quasi-experimental study consisted of all eligible hemodialysis patients in Hamadan teaching hospitals. All of 48 patient...

Sleep problems are prevalent in hemodialysis patients. Although several studies have investigated the sleep quality and its causes in hemodialysis patients, there is no report available on dream anxiety in hemodialysis patients. The aim of this study was to evaluate the sleep quality and dream anxiety in hemodialysis patients. We also investigated related factors which influence sleep quality a...

BACKGROUND/AIMS With advanced anticoagulation, many institutions operate continuous renal replacement therapy (CRRT) circuits longer than manufacturers' recommendations. This extended use may change hemodiafilter performance and clearance properties. However, hemodiafilter performance over time has not been assessed. We investigated solute clearance over time in modeled CRRT. METHODS In vitro...

BACKGROUND Peripherally inserted central venous catheters (PICCs) are commonly used intravenous access devices in children. Although PICCs are intended to be placed in central veins, many fail to reach this location. These noncentral PICCs are used for administration of medications and isotonic solutions. OBJECTIVES To examine the efficacy of noncentral PICCs for completion of therapy, the co...