The belief that cochleovestibular schwannomas arise from the glial-Schwann cell junction has repeatedly been quoted in the literature, although there is no published evidence that supports this statement. A systematic evaluation of the nerve of origin and the precise location of cochleovestibular schwannomas using our respective archival temporal bone collections was conducted. Forty tumors wer...

Homozygous deletion of the INK4a-ARF locus is one of the most frequent mutations found in human glioblastoma. We have previously shown that combined Ink4a-Arf loss can increase tumor incidence in both glial progenitor cells and astrocytes during mouse gliomagenesis. Here we have investigated the separate contribution of loss of each of the tumor suppressor genes in glial progenitor cells and as...

Background and Purpose: Malignant, non-enhancing supratentorial gliomas (G) and neuronal-glial (NG) tumors are sometimes misdiagnosed as low grade tumors. Earlier studies have indicated that up to 45% of the non-enhancing supratentorial gliomas are malignant. Diffusion tensor imaging (DTI) can supply multiple diffusion indices of which minimal apparent diffusion coefficient (ADC) and ratio Frac...

BACKGROUND Congenital intracranial tumors as a group are quite rare, representing only 0.5% to 1.5% of all pediatric brain neoplasms. CASE REPORT We reported a case of congenital mixed neuronal-glial tumor detected by ultrasound at 30 weeks of gestation. It showed that the tumor was 2.5 × 2.3 × 2.1 cm in size, located in the sellar region, regular shape, and slightly heterogeneous solid mass ...

#### Notable in Neurology This Week issue features an article that examines the long-term clinical benefits of RAF and MEK inhibitors adult patients with BRAF V600–mutant glial glioneuronal tumors; another looks at association between poverty exposure duration cognitive function decline among older adults China. A featured Special Article presents American Academy Neurology's position statement...

Tumor microenvironments are the result of cellular alterations in cancer that support unrestricted growth and proliferation further modifications cell behavior, which critical for tumor progression. Angiogenesis therapeutic resistance known to be modulated by hypoxia other microenvironments, such as acidic stress, both core features glioblastoma microenvironment. Hypoxia has also been shown pro...

Despite a considerable amount of information concerning chromosomal and molecular abnormalities found in gliomas in adults, relatively little is known regarding these abnormalities in pediatric brain tumors. We have analyzed DNA from 37 primary brain tumors and 4 tumor-derived cell lines for oncogene amplification. Probes utilized represent 11 known oncogenes (erbB1, gli, neu, myc, L-myc, N-myc...