Since the first bacterial genome, Haemophilus influenzae, was fully sequenced in 1995, over 1000 complete bacterial genome sequences have been determined. DNA sequencing technology has dramatically improved from the first generation, automated Sanger DNA sequencing, which dominated this field for almost two decades, to the current Nextgeneration sequencing protocols. This newer technology drama...

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OBJECTIVE As large-scale genome sequencing technology advances, concerns surrounding the reporting of individual findings to study volunteers have grown and fueled controversy. This is especially true in mental health research, where the clinical importance of sequencing results is particularly unclear. The ethical, legal, and social issues are being widely debated, but less is known about the ...

Whole genome sequencing datasets present the opportunity to not only study evolution in target organism, but also associated holobiont. The capacity epi-endobiotic kelp association...

The development of next generation sequencing (NGS) technologies has enabled the determination of whole genome sequences in many non-model plant species. However, genome sequencing in sweetpotato (Ipomoea batatas (L.) Lam) is still difficult because of the hexaploid genome structure. Previous studies suggested that a diploid wild relative, I. trifida (H.B.K.) Don., is the most possible ancestor...

The most valuable application of next generation sequencing (NGS) technology is genome sequencing. Genomes of several aquatic models had been sequenced in the past few years due to their importance in genomics, development biology, toxicology, pathology, and cancer research. NGS technology is greatly advanced in sequencing length and accuracy, which facilitate the sequencing process, but sequen...

The availability of genomes across the tree of life is highly biased toward vertebrates, pathogens, human disease models, and organisms with relatively small and simple genomes. Recent progress in genomics has enabled the de novo decoding of the genome of virtually any organism, greatly expanding its potential for understanding the biology and evolution of the full spectrum of biodiversity. The...