Eduardo D. Rosas-Blum1* Essam M. Imseis2* Richard W. McCallum3 1Paul L. Foster School of Medicine, Texas Tech University Health Science center at El Paso. Department of Pediatric, Division of Gastroenterology, Hepatology, and Nutrition 2University of Texas Health Science Center at Houston, Department of Pediatric, Division of Gastroenterology, Hepatology, and Nutrition 3Paul L. Foster School of...

BACKGROUND Patients with gastroparesis have significantly delayed gastric emptying because of impaired nerve function. Gastric neurostimulation from Enterra Therapy provides electrical pulses to the stomach tissue that promotes stimulation of stomach smooth muscle, thereby enhancing gastric emptying. This study evaluates the effectiveness of Enterra Therapy (Medtronic, Minneapolis, Minnesota) i...

Abstract Gastroparesis is a serious medical condition characterized by delayed gastric emptying. An innate immune dysregulation and injury to the interstitial cells of Cajal other components enteric nervous system likely central pathogenesis gastroparesis. We have done GWAS comparing idiopathic diabetic cases with controls as well contrasting versus cases. report novel genetic association SLC15...

Copyright © 2007 Massachusetts Medical Society. A 36-year-old man with a 20-year history of type 1 diabetes mellitus, background retinopathy, peripheral sensory neuropathy, and nephropathy presents with a history of several months of nausea and vomiting of undigested food and bile, during which time he lost 4 kg. On physical examination (performed 1 hour after the patient has eaten), his blood ...

BACKGROUND We present a case of amyloid light-chain amyloidosis with occult plasma cell dyscrasia, with the rare initial presentation of gastroparesis. While amyloidosis is known to affect the gastrointestinal system, rarely do patients present with gastrointestinal symptoms as their first symptom. To the best of our knowledge, this is the first such case reported with a definitive diagnosis ma...

Background and AimsThe role of decreased pyloric distensibility in gastroparesis as measured by the endolumenal functional luminal imaging probe (EndoFLIP) has been receiving increasing attention. In this study, we present clinical outcomes to dilation with esophageal FLIP (EsoFLIP) regard gastric emptying, symptom evolution, metrics.MethodsPatients evaluated for (gastric emptying studies t1/2 ...

Gastroparesis is a frequent and sometimes life-threatening complication of diabetes mellitus. Autonomic neuropathy seems to be one of the most important mechanisms underlying this entity, together with the other probable pathologies. The present study was performed in order to identify an alternative to gastric scintigraphy as a screening test. The gastric emptying times of 60 subjects (Group 1...

BACKGROUND The precise aetiology of chronic bloating remains poorly understood and underlying gastroparesis, small bowel bacterial overgrowth and colonic inertia may, individually or collectively, play a role. AIMS In this retrospective cohort analysis of symptomatic patients with chronic persistent bloating, we determined the clinical utility of wireless motility capsule and lactulose breath...

Tumor-associated gastroparesis, though reported in association with various malignancies, is rare in patients with cholangiocarcinoma. We report a 55-year-old woman who presented with dysphagia and recurrent vomiting. Esophagogastroduodenoscopy revealed dilated stomach and excess residue without organic obstruction. 99mTc sulfur colloid solid gastric emptying study, radio-opaque marker gut tran...