Gastric metaplasia is one of the factors in duodenal ulcer appearance. The aim of this study was to investigate the frequency of gastric metaplasia and its connection with age, sex, cigarette smoking and H. pylori infection. In the study 216 patients were included. There were 98 patients with duodenal ulcer, 60 with duodenitis, and 58 healthy control subjects. There was no statistically signifi...

Gum arabic is used throughout the world for various purposes including food additive and pharmaceutical excipient. The present study was undertaken to determine the effect of gum arabic on gastric ulcers in rats. The influence of gum arabic on the antiulcer activity of ranitidine, a known antiulcer drug was also evaluated. The antiulcer study was carried out in acetic acid induced chronic gastr...

After establishing the benign nature of a gastric ulcer, the treatment is primarily medical. This medical therapy is aimed to alleviate symptoms, to heal the ulcer and to prevent relapses. Based on the history of non-steroidal anti-inflammatory drugs (NSAIDs) and the Helicobacter pylori-status, gastric ulcer patients can be divided into four categories (1) H. pylori positive plus NSAID-use, (2)...

The objective of present study is to investigate anti-ulcer activity of Artocarpus heterophyllus Lam. leaves extracts on indomethacin induced ulcers in rats and establish the probable mechanism of antiulcer activity, if any and confirm the validity of claims of the activity as mentioned in texts as traditional medicines. The leaves were extracted with methanol and anti-ulcer activity was evalua...

BACKGROUND We hypothesized that neutralization of the gastric acidity by alkaline pancreatic secretion via a non-stented pancreaticogastrostomy after pylorus-preserving pancreaticoduodenectomy (non-stented PPPD-PG) might provide protection against marginal or stress ulcer. Surgical risk of non-stented pancreaticogastrostomy was also assessed to clarify the importance of stenting in pancreatic a...

Introduction Gastric ulcer disease has been recognized in foals and adult horses. It is a complex disease and lesions vary in anatomic distribution, severity and cause. In the neonatal foal (<30 days of age) gastric ulcers and mucosal desquamation have been documented in clinically normal foals [1-4]. Due to this finding many clinicians feel it is necessary to treat critically ill neonates prop...

Water, methanol and chloroform extracts of Landolphia owarensis were investigated for their effects on gastric acid secretion and ulceration in male albino rats. Two models of gastric lesion induced in experimental Wistar rats-HC1/ethanol-induced gastric lesions and Pylorus ligation-induced gastric lesions-were employed. In both models, the antiulcer activity of LA was compared with that of cim...

AIM Since there is an increasing need for gastric ulcer therapies with optimum benefit-risk profile. This study was conducted to investigate gastro-protective effects of N-acetylcysteine (NAC) against ethanol-induced gastric ulcer models in mice. MATERIALS AND METHODS A total of 41 mice were allocated into six groups consisted of 7 mice each. Groups 1 (normal control) and 2 (ulcer control) re...

Background: It is not yet known which types of Toll-like receptors (TLRs) are most effective in Helicobacter pylori (H. pylori) recognition. It is also not known which gastric zones have the most prominent roles in TLR-mediated bacterial recognition. The aim of this work was to analyze the expression of TLR2 and TLR4 in biopsy specimens from H. pylori-infected patients. Methods: Thirty-eight...

gastric ulcer is one of the most prevalent gastrointestinal (gi) disorders, which affects approximately 5-10% of people during their life. in recent years, plentiful works have been carried out on herbal medicine to clarify their potential efficacy in gastric ulcer prevention or management. tripleuro-spermum disciforme is one of the indigenous plants that is readily available and has been tradi...