A centrosomal serine/threonine kinase, AIK1(3)/breast tumor amplified kinase/aurora2, which was recently identified as an oncogene, shows high amino acid identity with chromosome segregation kinases, fly Aurora, and yeast Ipl1. Immunohistochemical analyses of invasive ductal adenocarcinomas of the breast revealed that overexpression of AIK1 was observed in 94% of the cases, irrespective of the ...

Two to 11% of women diagnosed with breast cancer will develop contralateral breast cancer in their lifetime. Women with a first primary are at a 2-6-fold increased risk of developing contralateral breast cancer compared with the risk in the general population of women developing a first primary cancer. The incidence rate of contralateral breast cancer varies from four to eight per 1000 person-y...

Expression and pharmacological studies support a contribution of cyclooxygenase (COX)-2 to mammary gland tumorigenesis. In a recent transgenic study, mouse mammary tumor virus promoter-driven COX-2 expression in mouse mammary glands was shown to result in alveolar hyperplasia, dysplasia, and carcinomas after multiple rounds of pregnancy and lactation. In the study presented here, the effects of...

Adenomyoepithelial adenosis of the breast is an extremely rare type of adenosis. We herein present the case of a 35-year-old woman, who presented with a small painless hard lump and elastic soft induration of 5 cm in diameter in her left breast. Clinical examination and diagnostic workup were suggestive of a breast carcinoma, and a modified radical mastectomy and sentinel node biopsy were perfo...

AD CONTRACT NUMBER DAMD17-96-C-6059 TITLE: MRI-Based Screen for Breast Cancer Patients Carrying a Breast Cancer Susceptibility Gene PRINCIPAL INVESTIGATOR: Mitchell D. Schnall, M.D, CONTRACTING ORGANIZATION: University of Pennsylvania Philadelphia, Pennsylvania 19104-3246 REPORT DATE: October 1998 TYPE OF REPORT: Annual PREPARED FOR: Commander U.S. Army Medical Research and Materiel Command For...

Breast cancer is the most common cancer in Singaporean women and the rate of increase in incidence is one of the highest in the world. In view of the significant contribution of delayed presentation to the disease burden in South East Asia, we reviewed the incidence of late presentation of breast cancer and the contributing factors in Singapore. Disease presentation was analysed using studies b...

OBJECTIVE To assess the relationships between maternal breast-feeding intention, attitudes, self-efficacy and knowledge at 7 months' gestation with exclusive or full breast-feeding at 3 months postpartum. DESIGN Prospective cohort study with structured home interviews during pregnancy and 3 months after delivery. SETTING Two rural sub-districts of Kishoreganj district, Bangladesh. SUBJECT...

[This corrects the article DOI: 10.1371/journal.pone.0119051.].