BACKGROUND There is considerable interest in the expression of cancer testis (CT) antigens in human cancers, because they may serve as the basis for diagnostic tests or an immunologic approach to therapy, or as prognostic markers. METHODS On this basis, we evaluated by semiquantitative reverse-transcriptase polymerase chain reaction (RT-PCR) the expression of genes that code for tumor antigen...

cancer is the second important reason of mortality in the world. in this regard melanoma was accounted as the most aggressive type of coetaneous cancer. among drug extracted from natural products from marine organisms have been focused investigations related to chemotherapeutic agents derived from echinoderms such as sea cucumbers and starfish.  in the present study, cytotoxic and apoptosis ind...

Objective(s): Growing evidences have indicated microRNAs as modulators of tumor development and aggression. On the other hand, a phenomenon known as epithelial-mesenchymal transition (EMT) that indicates a transient phase from epithelial-like features to mesenchymal phenotype is a key player in tumor progression.  In this study, we aimed to assess the potential impacts...

Chronic inflammatory demyelinating polyneuroradiculopathy (CIDP) is an immune mediated disorder characterized by progressive developing or relapsing symmetrical motor or sensory symptoms in more than one limb over a period of two months. Achalasia, as a primary esophageal motility disorder, is also characterized by increasing the tone of lower esophageal sphincter, absence or incomplete sphinct...

Introduction: cyclooxygenase-2 (COX-2) is involved in pathogenesis of various tumors and possibly malignant skin tumors including malignant melanoma; however, there is not enough information about COX-2 expression in benign melanocytic lesions. In the present study we compared the expression levels of COX-2 in malignant melanoma and benign melanocytic lesions. Method: In this analytical study, ...

zosteriform metastasis is a rare clinical distribution from spreading neoplasms of every organ to the skin. tumors most often arise from a n internal o r hematologic malignancy. w e report a 69-year-old man, a known case of malignant melanoma of the left heel. in this case, multiple red-brown metastatic nodules appeared four months after diagnosis. distribution of metastatic lesions resembled a...

malignant melanoma has the heart metastasis rate of 50 - 71%, which seems to be the highest among other malignancies. when a patient presents with cardiac metastases of melanoma, the disease has already spread through the body and therefore hardly curable. this brief review tried to introduce this important condition and discuss its frequency, presentation, diagnosis, histologic findings and tr...

  Introduction: Esophageal Squamous-Cell Carcinoma (SCC) is one of the most common malignancies in Iran. To reduce the incidence of esophageal SCC, it is important to recognize the controllable risk factors and prevent them. Celiac disease is widely known as a possible risk factor for esophageal SCC.  Thus, we decided to assess the frequency of celiac disease in esophageal SCC patients in North...