نتایج جستجو برای: esat 6 protein

تعداد نتایج: 2065964  

Journal: :Vaccine 2007
Alexander C Maue W Ray Waters Mitchell V Palmer Brian J Nonnecke F Chris Minion Wendy C Brown Junzo Norimine Monica R Foote Charles F C Scherer D Mark Estes

The potency of genetic immunization observed in the mouse has demonstrated the utility of DNA vaccines to induce cell-mediated and humoral immune responses. However, it has been relatively difficult to generate comparable responses in non-rodent species. The use of molecular adjuvants may increase the magnitude of these suboptimal responses. In this study, we demonstrate that the co-administrat...

Journal: :PLoS ONE 2006
Philip C. Hill Roger H. Brookes Annette Fox Dolly Jackson-Sillah Moses D. Lugos David J. Jeffries Simon A. Donkor Richard A. Adegbola Keith P. W. J. McAdam

BACKGROUND Options for intervention against Mycobacterium tuberculosis infection are limited by the diagnostic tools available. The Purified Protein Derivative (PPD) skin test is thought to be non-specific, especially in tropical settings. We compared the PPD skin test with an ELISPOT test in The Gambia. METHODOLOGY/PRINCIPAL FINDINGS Household contacts over six months of age of sputum smear ...

Journal: :PLoS ONE 2007
Jean-Michel Hougardy Kinda Schepers Sammy Place Annie Drowart Véronique Lechevin Virginie Verscheure Anne-Sophie Debrie T. Mark Doherty Jean-Paul Van Vooren Camille Locht Françoise Mascart

BACKGROUND The detection of latent tuberculosis infection (LTBI) is a major component of tuberculosis (TB) control strategies. In addition to the tuberculosis skin test (TST), novel blood tests, based on in vitro release of IFN-gamma in response to Mycobacterium tuberculosis-specific antigens ESAT-6 and CFP-10 (IGRAs), are used for TB diagnosis. However, neither IGRAs nor the TST can separate a...

2011
M Hemmati A Seghatoleslam M Rasti S Ebadat N Mosavari M Habibagahi M Taheri A R Sardarian Z Mostafavi-Pour

BACKGROUND One of the most widely used methods to detect tuberculosis (TB) infection is the tuberculin skin test (TST). The completion of Mycobacterium tuberculosis (M. tuberculosis) genome sequence has led to identification of several antigens that can be utilized for accurate diagnosis and control of TB. The aim of this study was to purify the recombinant M. tuberculosis antigens for the eval...

Journal: :International journal of clinical and experimental medicine 2014
Jianhang Leng Yu Ding Chengmin Shou Zhigang Wu Guangchao Zhuo Keyi Wang Junya Shen Sheng Huang

Tuberculosis (TB) is a major global public health problem with an estimated one-third of the world's population infected with Mycobacterium tuberculosis, thus necessitating fast and accurate diagnosis of TB. However, the diagnosis of latent infection remains difficult due to the lack of a simple, reliable test for M. tuberculosis infection. The objective of the current study was to generate and...

Journal: :Infection and immunity 2003
A O Whelan J C Hope C J Howard D Clifford R G Hewinson H M Vordermeier

The use of defined protein and peptide antigens can overcome specificity limitations of purified protein derivatives in the detection of bovine tuberculosis when the antigens are used in blood-based tests. Since the use of these specific antigens as skin test reagents could have practical advantages, we investigated the potential of Mycobacterium bovis-specific antigens to stimulate delayed-typ...

Journal: :BMC Infectious Diseases 2007
Valérie Martinez Guislaine Carcelain Edgar Badell Marc Jouan Isabelle Mauger Pierre Sellier Chantal Truffot François Bricaire Sandra M Arend Tom Ottenhoff Brigitte Autran Brigitte Gicquel

BACKGROUND The identification of antigens able to differentiate tuberculosis (TB) disease from TB infection would be valuable. Cellular and humoral immune responses to Erp (Exported repetitive protein)--a recently identified M. tuberculosis protein--have not yet been investigated in humans and may contribute to this aim. METHODS We analyzed the cellular and humoral immune responses to Erp, ES...

Journal: :The European respiratory journal 2012
Tobias Hodapp Urban Sester Ulrich Mack Mahavir Singh Thomas Meier Elisabeth Wiech Paul Fisch Stephan Ehl Martina Sester

T-cell responses towards tuberculin (purified protein derivative; PPD) or the Mycobacterium tuberculosis-specific antigens early secretory antigenic target (ESAT)-6 and culture filtrate protein-10 are indicative of prior contact with mycobacterial antigens. In this study, we investigated the exceptional case of a 75-yr-old patient who devoted more than one-third of his CD4 T-cells against PPD a...

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