Hypersynchronous neuronal excitation manifests clinically as seizure (ictogenesis), and may recur spontaneously and repetitively after a variable latency period (epileptogenesis). Despite tremendous research efforts to describe molecular pathways and signatures of epileptogenesis, molecular pathomechanisms leading to chronic epilepsy remain to be clarified. We hypothesized that epigenetic modif...

BACKGROUND AND PURPOSE Stroke is the major cause of acquired epilepsy. The mechanisms of ischemia-induced epileptogenesis are not understood, but glutamate is associated with both ischemia-induced injury and epileptogenesis in several models. The objective of this study was to develop an in vitro model of epileptogenesis induced by glutamate injury in hippocampal neurons as observed during stro...

The role of inflammation has been shown in the pathogenesis of epilepsy, while glucocorticoids and adrenaline have anti-inflammatory effects. The aim of the present study was to investigate the effects of adrenaline, prednisolone, and indomethacin on caffeine-induced epilepsy (epileptiform activity) in rats and to examine the mechanism of the pro-epileptic effect of indomethacin. The adrenalect...

The cholinergic mechanisms role determination in epileptogenesis attracts the attention of researchers. Pilocarpine administration rats contributes to chronic form epileptiform activity development characterized by presence a pronounced acute stage and an interictal period - free from behavioral convulsive reactions. We consider most important feature pilocarpine-induced seizures might be chang...

With the growth in antiepileptic drug treatment, the question arises as to what extent we are merely treating the symptom (i.e. the seizures) rather than the underlying disease process (i.e. epileptogenesis). Epileptogenicity can be considered as the process whereby structural and functional changes occur following an insult that in some cases result in epilepsy. Epileptogenicity also describes...

An association between acute CNS infections and seizures is reported in the literature. The etiology of these seizures is, in some cases, precipitated by epileptogenic pathogenesis of the infectious agent in the brain parenchyma. A different etiology of seizures as a consequence of infections, independent of the infectious agent, relates to the inflammatory reaction. Thirdly, the febrile respon...

The primary purpose of this topic is to collect scientific contributions providing novel insights in the cellular and molecular mechanisms of epileptogenesis as potential targets for innovative therapeutic approaches aimed at preventing the chronic epileptic disorder. Prevention of chronic epileptic disorder with an appropriate intervention might represent the most ambitious goal in the clinica...