background: indirect genetic diagnosis using polymorphic dna markers can detect carriers of hemophilia a. this technique is preferable in developing countries because of its simplicity and cost effectiveness compared to direct mutation analysis. in the present study, we examined usefulness of intragenic marker bcl i restriction fragment length polymorphism (rflp) at intron 18, for carrier detec...

Angiotensin-converting enzyme-2 (ACE-2) is an essential element in the renin-angiotensin RAS system and plays a key role coronavirus entrance to human body attachment cell. Variation ACE-2 may increase capability of binding with tissues lead variation disease severity among patients. For this reason, study aimed take some SNPs different COVID-19 patient cases show possible Angiotensin-Convertin...

the rs2476601 (r620w, c1858t) polymorphism in ptpn22 gene has been repeatedly reported to be associated with rheumatoid arthritis (ra). the rs 2476601 is widely suggested for predictive testing and risk assessment for ra. the aim of this study was to test the possible association of this snp with ra in iranian population.a total of 872 samples (405 confirmed ra patients and 467 healthy controls...

Introduction: Allergic Rhinitis (AR) is a common inflammatory disease of the nasal mucosa. The CD14 is a receptor for lipopolysaccharide and inhaled endotoxin which can stimulate the production of interleukins by antigen presenting cells. Accordingly, CD14 plays an important role in allergic and atopic diseases, which can be one of the etiological factors for allergic diseases. The present stud...

Aim To assess the association of GLO1 C332C gene polymorphism with breast cancer risk at different stages of the disease and to investigate the effect of this gene polymorphism on its mRNA expression and enzyme activity. Methods GLO1 C332C gene polymorphism was analyzed by PCR-RFLP in 100 healthy controls and 200 patients with breast cancer (100 patients with stage I & II and 100 patients wit...

BACKGROUND The results of studies on the association of ecNOS polymorphisms and vascular diseases are inconsistent. To explore the nature of this interaction in the absence of confounding factors, such as smoking, we measured ecNOS mRNA, protein, and enzyme activity in cultured human umbilical vein endothelial cells (HUVECs) with and without ecNOS polymorphisms. METHODS We identified a T(-786...

Background/Aim: Cervical cancer (CC) is the most common gynecological malignancy in women. In spite of a variety treatment protocols, it necessary to carefully investigate all factors that play role pathogenesis these tumors which may have mortal progression. this context, our study we aimed assess myeloperoxidase (MPO) gene polymorphism, an important inflammatory enzyme, among cervix cases. Me...