نتایج جستجو برای: endocrine related cancer
تعداد نتایج: 2032507 فیلتر نتایج به سال:
Targeted therapy in oncology consists of drugs that specifically interfere with abnormal signaling pathways that are dysregulated in cancer cells. Tyrosine kinase inhibitors (TKIs) take advantage of unique oncogenes that are activated in certain types of cancer, and also target common mechanisms of growth, invasion, metastasis, and angiogenesis. However, many kinase inhibitors for cancer therap...
Bisphenol A (BPA) has shown an ability to disrupt endocrine signaling in some human and animal model studies, raising suspicions that it may be a factor in the development of endocrine-related disorders, including breast cancer. Animal studies appear to support that suspicion, but the precise molecular mechanisms by which BPA exposure may lead to cancer in humans are poorly understood.2,3 Previ...
BACKGROUND Endocrine therapy is standard treatment for estrogen receptor (ER)-positive breast cancer. However, its efficacy is limited by intrinsic and acquired resistance. Here the potential of S100β as a biomarker and inhibition of its signaling network as a therapeutic strategy in endocrine treated patients was investigated. METHODS The expression of S100β in tissue and serum was assessed ...
Endocrine therapy is the treatment of choice in hormone receptor-positive breast cancer. However, the effectiveness of these agents is limited by the development of drug resistance, ultimately leading to disease progression and patient mortality. Whilst pre-clinical cell models of acquired endocrine resistance have demonstrated a role for altered growth factor signalling in the development of a...
Numerous studies have established a proof of concept that abnormal expression and function of estrogen receptors (ER) are crucial processes in initiation and development of hormone-related cancers and also affect the efficacy of anti-cancer therapy. Radiotherapy has been applied as one of the most common and potent therapeutic strategies, which is synergistic with surgical excision, chemotherap...
The standard of care for patients with hormone receptor positive, human epidermal growth factor receptor type 2 negative advanced breast cancer is endocrine therapy. Endocrine agents, including aromatase inhibitors, tamoxifen, and fulvestrant, are often administered alone as first line treatment and demonstrate durable responses with limited side effects. Endocrine resistance represents a major...
: Breast cancer is one of the most common malignancy in Chinese women. Up to 80% patients with metastatic breast develop bone metastasis resulting local destruction and skeletal-related events such as pathological fracture spinal cord compression. Skeletal-related pose an enormous impact on patients' motor function quality life. Therefore, prevention treatment objectives metastasis, which often...
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