نتایج جستجو برای: embryotoxicity

تعداد نتایج: 306  

Journal: :Molecular medicine 2012
Ian M Copple Amy E Mercer James Firman Gail Donegan Bram Herpers Michael Hl Wong James Chadwick Andreia D Bringela Maria L S Cristiano Bob van de Water Stephen A Ward Paul M O'Neill B Kevin Park

Semisynthetic artemisinin-based therapies are the first-line treatment for P. falciparum malaria, but next-generation synthetic drug candidates are urgently required to improve availability and respond to the emergence of artemisinin-resistant parasites. Artemisinins are embryotoxic in animal models and induce apoptosis in sensitive mammalian cells. Understanding the cytotoxic propensities of a...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2000
H Chen A G Fantel M R Juchau

Cytochrome P4503A7 (CYP3A7) is the primary CYP isoform expressed in human fetal hepatic microsomes, and its potential role in human embryotoxicity has attracted considerable investigative attention. In this study, we investigated the 4-hydroxylation of highly embryotoxic and teratogenic retinoic acids (RA) as catalyzed by human fetal liver microsomes (HFLM) and demonstrated that CYP3A7 is an ef...

2014
Qianying Guo Shuangjia Wang Yu Wang Liren Wei Han Zhu Lingyan Zhu Junli Shang Yong Li Junbo Wang

TT51, with a synthetic Cry1Ab/CryAc gene from Bacillus thuringiensis Berliner, was the first genetically modified (GM) plant officially certificated in China. This study was undertaken to investigate potential embryotoxicity of TT51 on rats. Whole embryo culture (WEC) is an effective method for safety evaluation when culture medium, containing substances derived from GM food, is available. Rat ...

Journal: :Environmental Health Perspectives 1994
W J Scott M D Collins H Nau

We have studied four organic acids of similar structure to further understand the basis of their developmental toxicity. Valproic acid (2-propyl pentanoic acid), ethylhexanoic acid, and octanoic acid are isomeric C8 organic acids but their teratologic potency varied widely. Valproic acid induced a moderate to severe teratologic outcome after a single oral administration of 6.25 mmoles/kg on day...

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