Purpose: To investigate the acetylcholinesterase (AChE) inhibitory potential of columbin and also to assess its binding affinity against AChE protein.
 Methods: Crystals were isolated from ethyl acetate fraction Tinospora cordifolia using column chromatography structure was determined x-ray crystallography. Ellman colorimetric assay used determine effect in vitro while molecular doc...

The total phenol content and the anti-acetylcholinesterase activity were compared in olive leaf (OL) extracts obtained using both subcritical water extraction (SbWE) conventional solvent (ethanol-water). method proposed by Ellman (in vitro) was used to study inhibitory of acetylcholinesterase (AChE). phenolic compounds AChE activities OL varied depending on method. Thus, extract technique (220 ...

The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) has made a serious public health threat worldwide. It many complications and deaths, so millions people are at risk in more countries. A special group consists patients with chronic diseases, particularly osteoarthritis. is known that development osteoarthritis associated oxidative...

Objective: Alcea genus belongs to Malvaceae family and this is represented by 85 taxa in the world 21 Flora of Turkey.The flowers contain plenty mucilage are used for treatment respiratory diseases such as asthma cough.Alcea dissecta known ‘Govik, Hiro, Hero’ Turkey, leaves species have been asthma,injury, colds, gastrointestinal Turkey. To best our knowledge, there no report on effect extracti...

Background and Objective: Changes of the enzyme acetylcholinesterase are involved in pathogenesis of different nervous disorders including Alzheimer’s disease. This research work was conducted to evaluate the inhibitory effect of Pistacia lentiscus ethanolic extract on acetylcholinesterase activity. Materials and Methods: Activity of the enzyme acetylcholinesterase (AChE) was measured by Ellman...

Factors such as oxidative stress and reduced acetylcholine level have been implicated in Alzheimer’s disease (AD) pathology and recently there has been a trend towards natural product research to find potential sources of antioxidants and acetylcholinesterase inhibitors in the plants kingdom. Centaurea is a genus with about 500 species world wild, many of them have shown to possess bio...

alcoholic extracts of 8 different types of seaweeds from iran's persian gulf were tested for their antimalarial and acetylcholinesterase enzyme (ache) inhibitory activities for the first time. a modified ellman and ingkaninan method was used for measuring ache inhibitory activity in which galanthamine was used as the reference. the antimalarial assay was performed using microculture radioisotop...

The goal of this work was the research chondroitin sulfate prophylactic action on glutathione system state in rat blood serum during acute joint inflammation. performed white non-linear pubertal males weighting 160-240 grams compliance to all general ethical principles animal research. All animals were divided four experimental groups. first group – control: injected with 0,1 ml 0,9 % NaCl solu...

Caffeine is an alkaloid with a stimulant effect in the body. It can interfere in transmissions based on acetylcholine, epinephrine, norepinephrine, serotonin, dopamine and glutamate. Clinical studies indicate that it can be involved in the slowing of Alzheimer disease pathology and some other effects. The effects are not well understood. In the present work, we focused on the question whether c...

OBJECTIVE To determine whether (i) cholinesterase activity is increased in the saliva of patients with primary Sjogren's syndrome (pSS), (ii) increased levels of cholinesterase of lymphocyte origin could interfere with the secretory activity of submandibular acinar cells, and (iii) hydroxychloroquine at therapeutic doses could interfere with cholinesterase activity. METHODS The Ellman method ...