A total of 32 drugs were evaluated as regards their efficacy for oral treatment of Ichthyobodo necator infestation of rainbow trout. In preliminary trials, all drugs were supplied to infected fish at 40 g per kg of feed for 10 d. The majority of the drugs tested (1,3-di-6-quinolylurea, aminosidine, amprolium, benznidazole, bithionol, chloroquine, diethylcarbamazine, dimetridazole, diminazene ac...

Poh, S. C (1974). Thorax, 29, 710-712. The course of lung function in treated tropical pulmonary eosinophilia. A follow-up study over a period of two years in the lung function of 15 patients with tropical pulmonary eosinophilia successfully treated with diethylcarbamazine is reported. A return to normal of the lung function with the exception of the transfer factor and forced expiratory volume...

New fluorescein and rhodamine B-labeled antifilarial drug DEC analogues for use in drug localization studies with confocal microscopy have been prepared by a high-yield three-step synthesis. The resulting beta-amine-substituted DEC analogue has a single ethyl substituent which is beta-aminated to accommodate the fluorophore of either fluorescein isothiocyananate or rhodamine B. Confocal microsc...

The aetiopathology of tropical eosinophilia presents a baffling problem in spite of a great deal of work on this subject in the last four years. The natural history of any disease rests on a good understanding of its pathology, and so far there have not been many pathological observations on the lung in this condition, possibly because of its apparently benign nature. This paper records the inv...

Diethylcarbamazine (DEC) was effective in reducing microfilarial densities of Brugia pahangi in Mongolian jirds (Meriones unguiculatus) when it was administered intraperitoneally at the daily dosage of 300 mg/kg of body weight either for 5 consecutive days or every 3 days for 43 days with the total of 15 doses. The latter treatment scheme seemed to be more effective than the former, suggesting ...

Fortifying salt with diethylcarbamazine (DEC) is a safe, low-cost and effective strategy to eliminate transmission of lymphatic filariasis. DEC-fortified salt has been used successfully in pilot projects in several countries and has been used operationally by China to eliminate lymphatic filariasis. The successful use of iodized salt to eliminate iodine-deficiency disorders is encouraging; simi...