Anxiolytic drugs may influence glycemic control in diabetic subjects, so the present study was conducted to investigate the effect of glimepiride, a commonly used oral hypoglycemic, diazepam, a commonly used anxiolytic, and their combination in STZ-induced diabetic rats. Diabetes was induced by streptozotpcin (50 mg/kg i.p.). Rats were divided into 5 groups namely: normal control, diabetic cont...

how to cite this article: fayyazi a, karimzadeh p, torabian s, damadi s, khaje a. comparison of intravenous midazolam drip with intermittent intravenous diazepam in the treatment of refractory serial seizures in children. iran j child neurol 2012; 6(3): 15-19.   objective serial seizures occur commonly in inpatient epileptic children. this type ofseizure due to its characteristics has a signifi...

Benzodiazepine use by patients in methadone and buprenorphine substitution treatment is common, despite safety concerns regarding these drug interactions. The relative safety of diazepam use by methadone- or buprenorphine-treated patients has not been systematically examined. This study aimed to examine the effect of single diazepam doses, within normal therapeutic range (doses: 0, 10, and 20 m...

A Prolonged convulsive seizure is the most common neurological medical emergency with poor outcome. An ideal anticonvulsant should be easy-to-use, effective, and safe, and it should also have a long-lasting effect. Benzodiazepines, give via the intravenous or rectal route have generally been used as first-line drugs. In small children, IV access can be difficult and time consuming. Midazolam is...

Claustrophobia is associated with cardiovascular magnetic resonance (CMR) due to the nature of the technique and lengthy examination times. We report the incidence and treatment of claustrophobia in a prospective study on the use of intravenous (IV) and oral diazepam for CMR from August 1997 to June 1999 in 1754 adult patients referred for clinical (1226) and research (528) purposes. Patients u...

Diazepam was metabolized to three primary metabolites, 3-hydroxy-diazepam, N-desmethyl-diazepam, and p-hydroxy-diazepam. Our previous studies reported metabolic position-specific inter- or intrastrain differences in diazepam metabolism among Sprague-Dawley, Brown Norway, Dark Agouti, and Wistar rats. Especially, there were marked ( approximately 300 fold) inter- or intrastrain differences in di...

Background: Benzodiazepines are regularly prescribed to treat patients in alcoholic withdrawal. After analyzing pharmacology of benzodiazepines, diazepam is faster metabolized and concentrated the liver, as an active metabolite whereas lorazepam liver by conjugation excreted urine. being a drug choice used with deranged functions needed be compared that diazepam. The objective study comparasion...

Lycium schweinfurthii is found in stony and sandy places belonging to the Solanaceae family which widely distributed North Africa Mediterranean area. The leaves fruits of this plant have traditionally been used for gastrointestinal diseases. This study was aimed evaluate neuropharmacological activity methanolic extract experimental animals. prepared by fractionation technique. Male Albino mice ...

how to cite this article : salehiomran mr, hoseini sm, ghabeli juibary a. intermittent diazepam versus continuous phenobarbital to prevent recurrence of febrile seizures: a randomized controlled trial. iran j child neurol. winter 2016;10(1):21-24. abstract objective febrile seizure is the most common neurologic problem in children between 3 months to 5 years old. two to five percent of children...

One hundred eighty-eight seizure episodes in 46 children were randomly assigned to receive treatment with rectal diazepam and intranasal midazolam with doses of 0.3 mg/kg body weight and 0.2 mg/kg body weight, respectively. Efficacy of the drugs was assessed by drug administration time and seizure cessation time. Heart rate, blood pressure, respiratory rate, and oxygen saturation were measured ...