The number of diabetic patients is increasing at an alarming rate and, according to the World Health Organisation, is estimated to reach 300 million worldwide by the year 2025. Coronary heart disease is the leading cause of death in these patients. Diabetic patients are 2 to 3 times more likely to develop coronary heart disease, and they experience worse clinical outcomes after coronary artery ...

OBJECTIVE Subjects with diabetes experience an increased risk of myocardial infarction and cardiac failure compared with nondiabetic age-matched individuals. The receptor for advanced glycation end products (RAGE) is upregulated in diabetic tissues. In this study, we tested the hypothesis that RAGE affected ischemia/reperfusion (I/R) injury in the diabetic myocardium. In diabetic rat hearts, ex...

AIMS Old age and diabetes are risk factors that often coexist increasing the vulnerability of the heart to the lethal effects of ischaemia-reperfusion injury (IRI). However, to our knowledge, no investigations have examined IRI and cardioprotective signalling in animal models bearing these co-morbidities concomitantly. The ability of the heart to recover following IRI is greatly dependent on it...

PURPOSE To compare body weight and length, heart weight and length, heart-to-body weight ratio, glycemia, and morphometric cellular data of offspring of diabetic rats (ODR) and of normal rats (control). METHODS Diabetes was induced in 3 pregnant Wistar rats, bearing 30 rats, on the 11th day after conception by intraperitoneal injection of 50 mg/kg of streptozotocin. Six normal pregnant Wistar...

Anderson EJ, Rodriguez E, Anderson CA, Thayne K, Chitwood WR, Kypson AP. Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways. Am J Physiol Heart Circ Physiol 300: H118–H124, 2011. First published November 12, 2010; doi:10.1152/ajpheart.00932.2010.— Progressive energy deficiency and loss of cardiomyocyte numbers are two prominent factors th...

Heart failure is a major and growing public health issue. Objective: The aim of this study was to describe the association between diabetes mellitus and heart failure. Methods: In this study 150 (78 males and 72 females) participants of Libyan attended Emergency department and Intensive Care in Tajoura National Heart Center and Tripoli Medical Center, were selected during the period from 4/2013...

Sudden cardiac death, also known as primary cardiac arrest (PCA), is a major cause of mortality among diabetic patients and typically occurs in the setting of coronary heart disease. Because it can occur as the first clinical manifestation of coronary heart disease, identifying diabetic patients at risk of PCA remains challenging. Interrelated sequelae of diabetes, including QT prolongation and...

Many diabetic patients suffer from cardiomyopathy, even in the absence of vascular disease. This diabetic cardiomyopathy predisposes patients to heart failure and mortality from myocardial infarction. Evidence from animal models suggests that reactive oxygen species play an important role in the development of diabetic cardiomyopathy. Our laboratory previously developed a transgenic mouse model...