A cluster of eight genes encoding glutathione transferases (GSTs) are located on division 33B of polytene chromosome arm 3R of the African malaria mosquito, Anopheles gambiae. This region of the genome contains a major 1,1,1-trichloro-2,2-bis-( p -chlorophenyl)ethane (DDT)-resistance locus, rtd1. These GSTs belong to the insect-specific Epsilon class and share between 22.6 and 65.2% identity at...

and economic costs on many poor countries. For South Africa, which has a relatively minor malaria problem for a developing country, from 2000 to 2002 the economic cost ranged between US$15 million and US$41 million, excluding estimates of the human suffering and estimates of lost investment in malarial areas. The methods of controlling and treating the disease are well known and include indoor ...

Knowledge on insecticide resistance in Anopheles species is a basic requirement to guide malaria vector control programs. In Lao PDR, vector control relies on insecticide residual spraying (IRS) and impregnated bed-nets (ITNs) with the use of pyrethroids. Here, the susceptibility of Anopheles species, including several malaria vectors (An. maculatus and An. minimus), to various insecticides was...

The planned upscaling of vector control strategies requires insight into the epidemiological consequences of vector resistance. Therefore, the pyrethroid and DDT resistance status of Anopheles gambiae s.l. was assessed in Uganda from 2004 to 2006, and spatial and seasonal variations in knockdown resistance (kdr) frequencies were analyzed in terms of epidemiological significance. Anopheles gambi...

OBJECTIVES To determine whether the re-introduction of DDT in KwaZulu-Natal had any effects on malaria transmission in the province. DESIGN, SETTING AND SUBJECTS The 2000 malaria epidemic in KwaZulu-Natal has been attributed to pyrethroid-resistant anopheles mosquitoes in the area. Previous studies have shown that these mosquitoes are still susceptible to DDT. To determine whether DDT re-intr...

Insecticide resistance is an ongoing challenge in agriculture and disease vector control. Here, we demonstrate a novel strategy to attenuate resistance. We used genomics tools target fundamental energy-associated pathways identified potential “Achilles' heel” for resistance, resistance-associated protein that, upon inhibition, results substantial loss the phenotype. Specifically, compared gene ...

the first records of anopheles fluviatilis resistance to ddt was reported in 1963 from india and to dieldrin from eastern saudi arabia in 1959. in southern iran, antimalaria measures began in 1950 and up to 1957 the area was under ddt residual house spraying at the rate of 2g /m2 one round/year. during 1958-59 dieldrin was used at 0.5 g/m2, 1or 2 rounds/year was applied in the lowland areas. in...

In 2006, the World Health Organization issued a position statement promoting the use of indoor residual spraying (IRS) with dichlorodiphenyltrichloroethane (DDT) for malaria vector control in epidemic and endemic areas. Other international organizations concurred because of the great burden of malaria and the relative ineffectiveness of current treatment and control strategies. Although the Sto...

Pyrethroids are powerful insecticides used in the vector control program with impregnated mesh, and residual indoor sprays. However, resistance to insecticide reduces effectiveness. The present susceptibility study carried out against theAnopheles Stephensi monitor sensitivity conditions of An. vector, which raises need understand state Dungarpur region Rajasthan, India order better report vect...

the genetics and mechanism of malathion resistance in the adults of an. stephensi (ban-s), was studied. nine successive generations of malathion selection in the adults resulted in an increase in ltso of about 3-fold. the crossing experiments indicated that the resistance is inherited as partially dominant character with no indication of sex linkage. the results of back-crosses suggested that p...