نتایج جستجو برای: cytoprotective
تعداد نتایج: 4389 فیلتر نتایج به سال:
Background & Aims: Hydrogen sulfide due to cytoprotective effects can be used in prevention and treatment of many disorders. The effects of hydrogen sulfide onhormonal system in rat kidneys with cisplatin (CP) nephrotoxicity are unknown. The purpose of the experiments was to survey the effects of hydrogen sulfide on rat kidneys hormonal system with cisplatin nephrotoxicity. Ma...
16, 16 Dimethyl prostaglandin E2 (dmPGE2), a known cytoprotective agent, was examined for its ability to alter the course of fulminant hepatitis in an experimental model of fulminant viral hepatitis, murine hepatitis murine hepatitis type 3 (MHV-3). Fully susceptible BALB/cJ mice, infected with 100 50% lethal doses (LD50) of MHV-3 developed histologic and biochemical evidence of fulminant hepat...
The metabotropic glutamate 1a (mGlu1a) receptor is a G protein-coupled receptor linked with phosphoinositide (PI) hydrolysis and with β-arrestin-1-mediated sustained extracellular signal-regulated kinase (ERK) phosphorylation and cytoprotective signaling. Previously, we reported the existence of ligand bias at this receptor, inasmuch as glutamate induced both effects, whereas quisqualate induce...
Therapeutic agents to the central nervous system (CNS) need to be efficiently delivered to the target site of action at appropriate therapeutic levels. However, a limited number of effective drugs for the treatment of neurological diseases has been developed thus far. Further, the pharmacological mechanisms by which such therapeutic agents can protect neurons from cell death have not been fully...
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