The ability of the skin to repair itself after injury is vital to human survival and is disrupted in a spectrum of disorders. The process of cutaneous wound healing is complex, requiring a coordinated response by immune cells, hematopoietic cells, and resident cells of the skin. We review the classic paradigms of wound healing and evaluate how recent discoveries have enriched our understanding ...

Very little literature is available about malignant cutaneous fungating wounds, and most of the research has been conducted in England. Although only a small number of patients with cancer develop the traumatic and devastating complication of a malignant cutaneous wound, it can be a very distressing occurrence. These patients usually are in the last few months of their lives, and the presence o...

Immune-modifying particles (IMPs) composed of biodegradable poly(lactic-co-glycolic acid) (PLGA-IMP) are taken up by circulating inflammatory monocytes via scavenger receptor MARCO and lead them to traffic the spleen where they undergo apoptosis. PLGA-IMPs has been demonstrated improve immune-mediated pathology in diverse tissues conditions. Here we report using intravenous for severe acute ski...

BACKGROUND Angiogenesis is crucial for wound healing and exogenous supplements of the angiogenic growth factors have been known to promote cutaneous wound healing. Angiopoietin (Ang) 1 is a recently discovered angiogenic factor and there have been few studies of its effect on cutaneous wound healing. OBJECTIVE We examined the effect of Ang 1 on cutaneous wound healing. METHODS Cartilage oli...

The study was designed to evaluate the effects of hydromethanolic extract of tuberous root of M. jalapa and its terpenoid and flavonoid fractions on cutaneous wound healing in Wistar Albino rats. The hydromethanolic extract was subfractionated by sequential extraction in solvents (moderately nonpolar to polar). The extract and its (terpenoid and flavonoid) fractions were used for cutaneous woun...

The use of laser therapy is one of the most effective tools in the prevention and treatment of skin ulcers. It is an effective treatment choice because it potentiates the trophic regenerative, anti inflammatory, and painkiller effects. This study aimed to assess the effectiveness of low level laser therapy in treating induced cutaneous ulcers in rats. An experimental study using 12 female Wista...