نتایج جستجو برای: ctgf

تعداد نتایج: 1816  

2009
Rudy F. Duisters Anke J. Tijsen Blanche Schroen Joost J. Leenders Viola Lentink Ingeborg van der Made Veronica Herias Rick E. van Leeuwen Mark W. Schellings Paul Barenbrug Jos G. Maessen Stephane Heymans Yigal M. Pinto Esther E. Creemers

The myocardium of the failing heart undergoes a number of structural alterations, most notably hypertrophy of cardiac myocytes and an increase in extracellular matrix proteins, often seen as primary fibrosis. Connective tissue growth factor (CTGF) is a key molecule in the process of fibrosis and therefore seems an attractive therapeutic target. Regulation of CTGF expression at the promoter leve...

Journal: :Stroke 2010
Jan Willem Leeuwis Tri Q Nguyen Maarten G J Theunissen Wouter Peeters Roel Goldschmeding Gerard Pasterkamp Aryan Vink

BACKGROUND AND PURPOSE Carotid plaques remodel toward a more stable phenotype after stroke, but not after TIA. Connective tissue growth factor (CTGF) is involved in extracellular matrix production and is expressed in atherosclerotic plaques. We studied the role of CTGF in plaque remodeling after stroke and TIA. METHODS Atherosclerotic plaques from carotid endarterectomy of asymptomatic patien...

Journal: :Diabetes 2007
Takeshi Kita Yasuaki Hata Kumiko Kano Muneki Miura Shintaro Nakao Yoshihiro Noda Hiroaki Shimokawa Tatsuro Ishibashi

The critical association of connective tissue growth factor (CTGF), which is thought to be one of the downstream mediators of transforming growth factor-beta (TGF-beta), with vitreoretinal diseases remains to be clarified. In the current study, we first demonstrated the correlation between the concentrations of TGF-beta2 as well as CTGF in the vitreous and CTGF gene regulation in cultured hyalo...

Journal: :Molecular pathology : MP 2001
M A Rageh E E Moussad A K Wilson D R Brigstock

AIMS To determine mechanisms regulating the production of connective tissue growth factor (CCN2; CTGF) and transforming growth factor beta1 (TGF-beta1) in the mouse uterus. METHODS In situ hybridisation and immunohistochemistry were used to localise CCN2 (CTGF) and TGF-beta1 in uteri from sexually mature female mice that had either been (1) mated with sterile males to induce pseudopregnancy o...

Journal: :Molecular cancer research : MCR 2006
Wenwen Chien Dong Yin Dorina Gui Akio Mori Jonathan Mordechai Frank Jonathan Said Donato Kusuanco Alberto Marchevsky Robert McKenna H Phillip Koeffler

Connective tissue growth factor (CTGF) is a secreted protein that belongs to CCN family. The proteins in this family are implicated in various biological processes, such as angiogenesis, adhesion, migration, and apoptosis. In this study, we explored the roles of CTGF in lung tumorigenesis. The expression levels of CTGF in 58 lung cancer samples were reduced by >2 fold in 57% of the samples comp...

2016
Vaishnavi Jadhav Qianyi Luo James M. Dominguez Jude Al-Sabah Brahim Chaqour Maria B. Grant Ashay D. Bhatwadekar

Period 2-mutant mice (Per2m/m), which possess a circadian dysfunction, recapitulate the retinal vascular phenotype similar to diabetic retinopathy (DR). The vascular dysfunction in Per2m/m is associated with an increase in connective tissue growth factor (CTGF/CCN2). At the molecular level, CTGF gene expression is dependent on the canonical Wnt/β-catenin pathway. The nuclear binding of β-cateni...

Journal: :Acta biochimica et biophysica Sinica 2006
Amrita Dosanjh

Connective tissue growth factor (CTGF) is a cysteine-rich protein that promotes extracellular matrix deposition. CTGF is selectively induced by transforming growth factor beta and des-Arg kallidin in lung fibroblasts and increases steady-state mRNA levels of alpha type I collagen, 5alpha-integrin and fibronectin in fibroblasts. Bronchial epithelial cells have been proposed to functionally inter...

Journal: :The Journal of investigative dermatology 2005
Suvi-Katri Leivonen Lari Häkkinen David Liu Veli-Matti Kähäri

Connective tissue growth factor (CTGF) is secreted by fibroblasts stimulated with transforming growth factor-beta (TGF-beta). CTGF is a potent enhancer of fibroblast proliferation, chemotaxis, and extracellular matrix deposition, and it is thought to mediate some of the fibrogenic effects of TGF-beta. Here, we have elucidated signaling pathways involved in regulating the TGF-beta-induced produc...

2015
Karin G. F. Gerritsen Jan Willem Leeuwis Maarten P. Koeners Stephan J. L. Bakker Willem van Oeveren Jan Aten Lise Tarnow Peter Rossing Jack F. M. Wetzels Jaap A. Joles Robbert Jan Kok Roel Goldschmeding Tri Q. Nguyen

Connective tissue growth factor (CTGF; CCN2) plays a role in the development of diabetic nephropathy (DN). Urinary CTGF (uCTGF) is elevated in DN patients and has been proposed as a biomarker for disease progression, but it is unknown which pathophysiological factors contribute to elevated uCTGF. We studied renal handling of CTGF by infusion of recombinant CTGF in diabetic mice. In addition, uC...

Journal: :Diabetes care 2004
Peggy Roestenberg Frans A van Nieuwenhoven Lotte Wieten Peter Boer Theo Diekman Anna M Tiller Wilmar M Wiersinga Noelynn Oliver William Usinger Stephen Weitz Reinier O Schlingemann Roel Goldschmeding

OBJECTIVE Connective tissue growth factor (CTGF) is strongly upregulated in fibrotic disorders and has been hypothesized to play a role in the development and progression of diabetes complications. The aim of the present study was to investigate the possible association of plasma CTGF levels in type 1 diabetic patients with markers relevant to development of diabetes complications. RESEARCH D...

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