Development of effective antibacterial agents for the treatment of infections caused by Gram-positive bacteria resistant to existing antibiotics, such as methicillin-resistant Staphylococcus aureus (MRSA), is an area of intensive research. In this work, the antibacterial efficacy of two antimicrobial peptides derived from plectasin, AP114 and AP138, used alone and in combination with monolaurin...

Objective: The aim of this study to manufacture the prolonged release lipid nanoparticle (Solid and nanostructure carrier) repaglinide for enhance oral bioavailability. Methods: Solid nanoparticles (SLN) Nanostructured carriers (NLC) were prepared by slight modification in solvent diffusion method. core material used as cetyl alcohol while blend with oleic acid was preparation NLC dispersion. T...

Lemongrass is a plant that produces essential oils, which contain citronellal, citronellol, and geraniol. These compounds are known to be used as antimicrobials antioxidants. Nanotechnology one of the technological innovations can medium for sending non-polar active components, such oils. The research was study effect citronella oil concentration, surfactant-cosurfactant ratio, speed homogeniza...

Objective: Nanoemulsions consist of fine oil-in-water dispersions, with droplets covering the size range 50–500 nm. Olive oil is frequently utilized in cosmetic and pharmaceutical topical product for its healing, protecting, moisturizing properties due to high fatty acid antioxidant content. In present work, a nanoemulsion composed olive oil, Span 80 as surfactant, Labrasol cosurfactant was dev...

Soursop leaves ( Annona muricata L.) chloroform extract has an anticancer agent that can be developed for traditional medicine preparation, even though the extract's solubility is low in water. This study aims to generate new soursop Self-Nano Emulsifying Drug Delivery System (SNEDDS). The expected result increases so drug delivery system more effective. extraction process of uses percolation m...

Abstract: Background/Objectives: The objective of the study was to examine feasibility extrusion/ spheronization techniques for formulation castor oil loaded self-emulsifying pellets. also aimed at optimization pellet system with design experiments. Materials and Methods: Various surfactants co-surfactants were tested their ability emulsify oil. proportion components (castor oil, surfactant co-...

in this work, we report synthesis of superparamagnetic iron oxide nanoparticles at room temperature using microemulsion template phase consisting of cyclohexane, water, cetyltrimethylammonium bromide ctab as cationic surfactant and butanol as a cosurfactant. silica surface modification of the as prepared nanoparticles was performed by adding tetraethoxysilane teos to alkaline medium. the struct...

The aim of this study was to prepare and characterize a self-emulsifying drug delivery system (SEDDS) with a high drug load of poorly water-soluble atorvastatin for the enhancement of dissolution and oral bioavailability. Solubility of atorvastatin in oil, surfactant, and cosurfactant was determined. Pseudo-ternary phase diagrams were constructed by the aqueous titration method, and formulation...

Flutamide (FLT) is an antiandrogen drug for the treatment of prostate cancer. It has the drawback of poor water solubility and needs enhancement of its dissolution rate in simulated gastric fluids. Hence, it is prepared as self-nanoemulsifying drug delivery systems (SNEDDS) with an aim to enhance its dissolution rate. The objectives of the study are to develop SNEDDS of FLT and to characterize ...