Random samples are : (1) Allergens are environmental agents which do not satisfy the classical definition of antigens. The protein nature of the active agents in pollen is in doubt. An allergen is identified by its reaction on the body. Many substances form, at .the site of injection, conjugate proteins which are antigens. (2) In skin testing the patient should have discontinued all medication ...

The effect of cortisone on the sequestration of (a) antibody-coated red cells and (b) incubated red cells was studied in rats. Cortisone administration inhibited the hepatic sequestration of red cells altered by non-immune as well as by immune injury. There was a latent period of 2 days between the institution of cortisone therapy and its first manifest effect on hepatic sequestration. The sple...

l. Analytical procedures for anserine, carnosine and related histidine compounds in skeletal muscles are given. 2. The anserineicarnosine ratio in the skeletal muscles of the rat increases with age, cortisone injection and lowered food intake, and in the guinea pig muscle with strenuous exercise. 3. The total anserine plus carnosine in leg muscles of the cat remain constant during long periods ...

Intravenous injection of 25 micrograms of bacterial endotoxin on day 9 of growth of the SA1 sarcoma results in extensive necrosis of the core of this tumor and in its subsequent complete regression. Tumor hemorrhagic necrosis and regression failed to occur in mice that were given a subcutaneous injection of cortisone acetate or dexamethasone 12 h before being giving endotoxin. Inhibition of tum...

The gross teratologic effects of cortisone on the fetal development of mice have been investigated extensively. Cortisone injected into pregnant mice on days 11, 12, 13, and 14 of pregnancy will cause cleft palate without cleft lip at a frequency that is dependent on the maternal and paternal genotypes.1'2 In addition to cortisone, cleft palate can be induced by a large number of environmental ...

The initial reports (Hench, Kendall, Slocumb, and Polley, 1949; Sprague, Power, Mason, Albert, Mathieson, Hench, Kendall, Slocumb, and Polley, 1950; Hench and others, 1950) of the antirheumatic potency of cortisone emphasized the fact that excessive doses produced not only desirable but also certain undesirable effects. At that time (1949), we expressed our hope and belief that analogues superi...

Since Hench and Kendall'"4 demonstrated the beneficial effect of ACTH and cortisone on rheumatoid arthritis and rheumatic fever, numerous reports on the influence of these drugs on tissue response to various injuries, and on granulation tissue have appeared. Systemically administered cortisone19'2and locally administered hog adrenal extract' depressed the formation of granulation tissue in woun...

INTRODUCTION There is a pressing need to identify diagnostic testing for Cushing's syndrome that can be achieved with ease and at low cost. This study aimed to explore the usefulness of late-night and post-overnight 1-mg dexamethasone suppression salivary cortisone, as measured by liquid chromatography-tandem mass spectrometry, for investigation of hypercortisolism. METHODS Salivary cortisone...

The object of the present article is to discuss the uses and limitations of cortisone therapy in *diseases of the gastro-intestinal tract, liver and pancreas. The term cortisone will often be used generically to embrace all forms of corticosteroid therapy, but it must be appreciated that the various steroids are nQt in every case interchangeable, and in particular that corticotrophin (ACTH) has...

Ttiis is a useful book, in which the place of cortisone and other steroid drugs in the treatment of the rheumatic diseases is reviewed. The book falls naturally into two parts. The first section conisists of five chapters, and is concerned with the use of cortisone in rheumatoid arthritis. The second section consists of two chapters, the first of which decribes the general use of cortisone in d...