Abstract Objective to correlate socio-demographic and health variables of elderly people different age groups with frailty. Method this is a quantitative, cross-sectional study conducted 50 individuals seen at Gerontology Outpatient Clinic in the interior São Paulo. Socio-demographic data were collected, including: frailty, cognitive performance, dependence on Basic Instrumental Activities Dail...

The concept of frailty has been defined as a multidimensional syndrome characterized by the loss of physical and cognitive reserve that predisposes to the accumulation of deficits and increased vulnerability to adverse events. Frailty is strongly correlated with age, and overlaps with and extends aspects of a patient's disability status (that is, functional limitation) and/or burden of comorbid...

Globally, the proportion of older adults is increasing. Older people face chronic conditions such as sarcopenia and functional decline, which are often associated with disability and frailty. Proteomics assay of potential serum biomarkers of frailty in older adults. Older adults were divided into non-frail and frail groups (n = 6 each; 3 males in each group) in accordance with the Chinese-Canad...

BACKGROUND Geriatric syndromes, including frailty, are common in older adults and associated with adverse outcomes. We compared patients described in clinical notes as "frail" to other older adults with respect to geriatric syndrome burden and healthcare utilization. METHODS We conducted a retrospective cohort study on 18,341 Medicare Advantage enrollees aged 65+ (members of a large nonprofit...

Background: Frailty is associated with increased risk of hospitalization in diabetic patients. Both SARS-CoV-2 pandemic and type 2 diabetes mellitus contribute to the frailty. In this study we aimed observe clinical laboratory indices subjects during COVID-19 who were either frail or not according Edmonton score. Material methods: During era, 100 consecutive patients divided into two groups as ...

Data of the Danish Twin Registry on monozygotic and dizygotic twins are used to analyse genetic and environmental influences on susceptibility to heart diseases for males and females, respectively. The sample includes 7955 like-sexed twin pairs born between 1870 and 1930. Follow-up was from 1 January 1943 to 31 December 1993 which results in truncation (twin pairs were included in the study if ...

Background Frailty, expressed as accumulation of health deficits in older adults, could contribute to the risk cognitive decline. We cross-sectionally studied brain connectivity signatures frailty The Irish Longitudinal Study on Ageing (TILDA). Method included participants from Wave 3 TILDA who underwent resting-state functional MRI. Connectivity maps were based Shen’s parcellation and connecto...

When analyzing correlated time to event data, shared frailty (random effect) models are particularly attractive. However, the estimation of such models has proved challenging. In semiparametric models, this is further complicated by the presence of the nonparametric baseline hazard. Although recent years have seen an increased availability of software for fitting frailty models, most software p...

Objectives Frailty is a common problem in patients with type 2 diabetes mellitus (T2DM). It considered to be associated inflammation. Novel markers derived from hemogram, such as neutrophil/lymphocyte ratio (NLR) and mean platelet volume/lymphocyte (MPVLR), are proposed inflammatory markers. In present study, we aimed compare NLR MPVLR levels of frail T2DM non?frail diabetic subjects. Methods D...

Cause-specific mortality data on Danish monozygotic and dizygotic twins are used to analyze heritability estimates of susceptibility to coronary heart disease (CHD) after controlling for smoking and Body Mass Index (BMI). The sample includes 1209 like-sexed twin pairs born between 1890 and 1920, where both individuals were still alive in 1966. The participants completed a questionnaire in 1966 ...