results the bacteriophage, designated mj1, was isolated by testing against a clinical mdr e. coli 3 strain. the mj1 phage showed a wide range of heat and ph stability. the phage morphology, determined by transmission electron microscopy, revealed a structure comprised of a head (108 ± 0.2 nm long by 128 ± 0.5 nm wide) and a contractile tail (123 ± 0.5 nm long by 15 - 26 nm wide). these features...

Studying the functioning of various body systems in different vertebrates is one key tasks comparative physiology. Teleost fishes are a large group vertebrates; however, mechanisms their digestive tract poorly understood and known mainly for such model object as Danio rerio. The aim this work was to characterize participation subtypes M-cholinergic receptors Rho-kinase enzyme cholinergic contra...

PURPOSE Detrusor instability is a common problem in the elderly, which is usually treated with anti-cholinergic medication. This study investigates the effect of erythromycin on rat detrusor muscle contractile response to characterise its potential as an alternative inhibitor of bladder muscle contraction. MATERIALS AND METHODS Strips of rat detrusor muscle were suspended in a perfusion organ...

The mechanism of alpha1-adrenoceptor-mediated contraction was investigated in helical strips of the rat-tail artery. Muscle strips with the endothelium removed contracted in response to the alpha1-adrenoceptor agonist cirazoline, with half-maximal contraction at 0.23 microM. The contractile response to a submaximal concentration of cirazoline (0.3 microM) was biphasic, with a rapid phasic compo...

objective: the use of drugs with herbal origin is increasing for treatment of gastrointestinal (gi) disorders. rosa damascena (r. damascena) is a well-known plant suggested to have beneficial effect on gi system. in this study, the effect of aqueous fraction of r. damascena on the contractionsofisolated guinea pig ileum was investigated. materials and methods: aqueous fraction of plant was obta...

We investigated the contractile role of M2 muscarinic receptors in mouse urinary bladder. When measured in the absence of other agents, contractions elicited to the muscarinic agonist oxotremorine-M exhibited properties consistent with that expected for an M3 response in urinary bladder from wild-type and M2 knockout (KO) mice. Evidence for a minor M2 receptor-mediated contraction was revealed ...