The effects of the cytochrome P450 inhibitors clotrimazole, ketoconazole, and 1-aminobenzotriazole (1-ABT) on native delayed rectifier (K(DR)) and cloned Kv1.5 (RPV Kv1.5) K+ channels of rabbit portal vein (RPV) myocytes were determined using whole-cell and single channel patch-clamp analysis. Clotrimazole reduced K(DR) and RPV Kv1.5 whole-cell current with respective Kd values of 1.15 +/- 0.39...

OBJECTIVES Microbial adhesion and biofilms have important implications for human health and disease. Candida albicans is an opportunistic pathogen which forms drug-resistant biofilms that contribute to the recalcitrance of disease. We have developed a high-throughput screen for potentiators of clotrimazole, a common therapy for Candida infections, including vaginitis and thrush. The screen was ...

background and purpose: otomycosis is an acute, subacute or chronic fungal infection of the pinna, the external auditory meatus and the ear canal caused mainly by several species of saprophytic fungi. lamisil (terbinafine) is an allylamine antifungal agent, that is used both in the topical and oral administration for the treatment of dermatophytosis, cutaneous candidiasis, and the pityriasis ve...

Dutta AK, Khimji A, Sathe M, Kresge C, Parameswara V, Esser V, Rockey DC, Feranchak AP. Identification and functional characterization of the intermediate-conductance Ca -activated K channel (IK-1) in biliary epithelium. Am J Physiol Gastrointest Liver Physiol 297: G1009–G1018, 2009. First published September 17, 2009; doi:10.1152/ajpgi.00223.2009.—In the liver, adenosine triphosphate (ATP) is ...

BACKGROUND The Pharmaceutical Society of Australia have developed "guidance" for the supply of several medicines available without prescription to the general public. Limited research has been published assessing the effect of these guidelines on the provision of medication within the practice of pharmacy. OBJECTIVE To assess appropriate supply of non-prescription antifungal medications for t...

the purpose of this study was to determine the therapeutic efficacy of citric and tartaric acids on experimental dermatophytosis in guinea pigs. in this study, the susceptibility of trichophyton mentagrophytes var. mentagrophytes to citric and tartaric acids was assessed using the macrodilution broth method. in the animal experiments, a cream consisting of the mixed acids was topically applied ...

The widespread emergence of antifungal drug resistance poses a severe clinical problem. Though predicted to play a role in this phenomenon, the drug:H(+) antiporters (DHA) of the major facilitator superfamily have largely escaped characterization in pathogenic yeasts. This work describes the first DHA from the pathogenic yeast Candida glabrata reported to be involved in antifungal drug resistan...