Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) are pathological overlapping and important causes of dementia for which clinical trials are in their infancy. Cholinesterase inhibitors may be of benefit in DLB and PDD, as suggested by placebo-controlled clinical trials of rivastigmine and donepezil. The anti-psychotic agent clozapine has been of benefit in PD and PDD,...

BACKGROUND Cognitive impairment is one of the core features of schizophrenia. For its evaluation, current clinical practice relies on detailed neuropsychological batteries which require trained testers and considerable amount of time to administer. Therefore, a brief and reliable screening tool for identification of overall cognitive impairment prior to a detailed comprehensive neurocognitive a...

Specific phobias are among the most common psychological problems (Kessler et al. 2005); however, specific phobias are seldom the primary reason that individuals seek treatment (Brown et al. 2001b). Because specific phobias are rarely the focus of clinical attention, there is a common—though in many cases mistaken—perception that specific phobias are straightforward and uncomplicated. In additi...

Synaptic dysfunction is linked to cognitive symptoms in Alzheimer's disease. Thus, measurement of synapse proteins in cerebrospinal fluid may be useful biomarkers to monitor synaptic degeneration. Cerebrospinal fluid levels of the postsynaptic protein neurogranin are increased in Alzheimer's disease, including in the predementia stage of the disease. Here, we tested the performance of cerebrosp...

introduction toxoplasma gondii is one of the most important pathogen that has adverse effect on reproductive function. evidence acquisition recent studies revealed that infection with t. gondii not only affect female reproduction, also cause male reproductive impairment. in clinical studies, high prevalence of toxoplasmosis in sterile men has been reported. in animal models, toxoplasmosis is as...

This study explored the psychometric properties of Online Sexual Addiction Questionnaire (OSA-Q). In total, 100 sexual offenders completed OSA-Q Spanish version, along with Millon Clinical Multiaxial Inventory-III (MCMI-III) for assessment related impairment. Thirty-four individuals social-desirability bias were extracted from sample. A four-factor structure accounted 77% variance and internal ...

HIV-associated neurocognitive disorders (HAND) are chronic complications of HIV infection in the central nervous system. Clinical presentations include asymptomatic impairment (ANI), mild (MND), and dementia (HAD). In era combination antiretroviral therapy (cART), prevalence HAD has significantly decreased, but rates ANI MND have increased, impairing patients’ daily functioning, medical adheren...