results the allele and genotype distributions of pnpla3 rs738409 and rs2281135 were not significantly different between the chb and lc groups. after segregation on the basis of sex, no significant correlation between pnpla3 (rs738409 and rs2281135) genotypes/alleles and liver cirrhosis was detected. moreover, none of the haplotypes in pnpla3 (rs738409 and rs2281135) was found to be statisticall...

background serum apoptotic cytokeratine 18 neoepitope m30 (ck-18 m30) and matrix metalloproteinase 2 (mmp-2) have been popular markers for detecting liver fibrosis in recent years. ck-18 is a major intermediate filament protein in liver cells and one of the most prominent substrates of caspases during hepatocyte apoptosis. mmp-2 plays an important role in tissue remodeling and repairing process...

conclusions these findings indicate that telbivudine, used in both monotherapy and combination therapy, improves the renal function of patients with chb. the improvements are particularly significant in patients at high renal risk. patients and methods this study included 336 chinese chb patients, who were selected from outpatients in tongji hospital. 44, 122, 66, 58, and 46 of these patients h...

background hepatitis b virus (hbv) is among the leading causes of liver cirrhosis worldwide. predictors of cirrhosis in iranian chronic hepatitis b (chb) patients are yet to be clearly identified. objectives evaluating the predictive factors of liver cirrhosis in chb. patients and methods a longitudinal study was conducted during 1995 - 2014 on all chb patients who were referred to tehran hepat...

conclusions this study showed that cccdna can be detected in the plasma specimen of 17.9% of iranian treatment-naive patients with chronic hepatitis b infection. therefore, designing prospective studies focusing on the detection of cccdna in these patients would provide more information. results the mean (sd) age of the patients was 41.1 ± 12.4 years (range, 20 - 62 years). from a total of 106 ...

results in a group of adult patients with chb, anxa2 values were far higher than those of the control group (p = 0.001). when we assessed anxa2 levels based on fibrosis stages, serum anxa2 levels of patients with early stage fibrosis (stages 1 - 3) were significantly higher than those of patients with advanced stage fibrosis (stages 4 - 5; p = 0.001). patients and methods this study included 17...

background to estimate the total annual cost due to chronic hepatitis b (chb)-related diseases imposed on each patient and his/her family in iran.   methods economic burden of chb-related diseases (chb, cirrhosis, and hepatocellular carcinoma) were examined. in this retrospective study, 100 iranian patients were identified to obtain their socioeconomic status, utilization (direct and indirect c...

background hepatitis b is the most common chronic viral infection in humans and the most common cause of death among viral hepatitis. as 70% to 80% of chronic hepatitis cases are caused by hbv in iran, this virus alone is considered the most important cause of liver diseases and the major cause of mortality arising from viral hepatitis cases in iran. objectives we planned this study to determin...

background chronic hepatitis b is one of the most common causes of cirrhosis and hepatocellular toxicity in many countries, including iran. cytotoxic t lymphocyte (ctl) and natural killer (nk) cells are the two of main cell populations considered as cytotoxic cells. one of the distinct pathways ctl and nk cells exert cytotoxicity is perforin/granzyme. after the cytotoxic cell/target cell juncti...