In this study, we review mechanoregulatory roles for perlecan in load-bearing connective tissues. Perlecan facilitates the co-acervation of tropoelastin and assembly elastic microfibrils translamellar cross-bridges which, together with fibrillin elastin stabilise extracellular matrix intervertebral disc annulus fibrosus. Pericellular interacts collagen VI XI to define stabilize compartment whic...

Acute exposure of A549 cells to Ag-NPs induces stronger effects on DNA integrity, ROS level, cell metabolism and cycle than repeated exposure. dissolves in both conditions Ag ions recombine with thiolated proteins.

In today’s media world, when journal publications seem at times to be outdated by the time they appear in print, oncologists are fascinated to find that experiments reported some 80 years ago could be the object of surprising new discoveries. And yet, that is precisely the setting for the CCR Focus published in this issue of Clinical Cancer Research. In 1931, Otto Warburg (top photo) was awarde...

dopaminergic signaling is one of the regulatory pathways being investigated for its implication in glucose metabolism. the aim of this study was to determine the effect of cabergoline on biochemical and anthropometric parameters in prediabetes stage (impaired fasting glucose and impaired glucose tolerance). in this double blind, placebo-controlled, pilot study, 27 prediabetic adults were random...

objective: the anti-cancer properties of curcumin, a poliphenol extract from the rhizome of curry, has been confirmed by many investigators. however, low levels of uptake, tissue distribution and rapid metabolism has limited its application as an anti-cancer drug. this study is aimed at increasing curcumin's water solubility due to a biodegradable, neutral and non-toxic micellar nano-carrier ca...

Dopaminergic signaling is one of the regulatory pathways being investigated for its implication in glucose metabolism. The aim of this study was to determine the effect of cabergoline on biochemical and anthropometric parameters in prediabetes stage (impaired fasting glucose and impaired glucose tolerance). In this double blind, placebo-controlled, pilot study, 27 prediabetic adults were random...

The book represents the written minutes of the symposium on "Regulation of Cell Metabolism" held in London on July 28-30, 1958, sponsored by the Ciba Foundation. There is no problem of greater importance to the basic understanding of biology than the study of the autoregulatory mechanisms of the cell. The participants in this conference are all leaders in the field of biochemistry and the discu...

Molecular imaging of tumor metabolism has gained considerable interest, since preclinical studies have indicated a close relationship between the activation of various oncogenes and alterations of cellular metabolism. Furthermore, several clinical trials have shown that metabolic imaging can significantly impact patient management by improving tumor staging, restaging, radiation treatment plann...

the anti-cancer activity of metal ions in the lanthanide group is being considered recently. it has been reported that cerium salts might stimulate the metabolism and therefore, produce anti-cancer effects. however, little is known about the effects of protein-cerium complex in controlling cancer cell growth. the aim of the present study was to elucidate the possible pathways for the cytotoxic ...

The role of DNA methylation in cardiomyocyte physiology and cardiac disease remains a matter controversy. We have recently provided evidence for an important DNMT3A human cell homeostasis metabolism, using engineered heart tissue (EHT) generated from induced pluripotent stem (hiPSC)-derived cardiomyocytes carrying knockout the de novo methyltransferase DNMT3A. Unlike isogenic control EHT, EHT d...