نتایج جستجو برای: ccl17

تعداد نتایج: 455  

Journal: :The Journal of biological chemistry 2016
Judith Alferink Sabine Specht Hannah Arends Beatrix Schumak Kim Schmidt Christina Ruland Ramona Lundt Andrea Kemter Andrea Dlugos Janina M Kuepper Karola Poppensieker Matthias Findeiss Önder Albayram David-M Otte Janine Marazzi Jürg Gertsch Irmgard Förster Wolfgang Maier Stefanie Scheu Achim Hoerauf Andreas Zimmer

Cerebral malaria is a severe and often fatal complication of Plasmodium falciparum infection. It is characterized by parasite sequestration, a breakdown of the blood-brain barrier, and a strong inflammation in the brain. We investigated the role of the cannabinoid receptor 2 (CB2), an important modulator of neuroinflammatory responses, in experimental cerebral malaria (ECM). Strikingly, mice wi...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2012
Anh Thu Nguyen Hoang Puran Chen Julius Juarez Patty Sachamitr Bo Billing Lidija Bosnjak Barbro Dahlén Mark Coles Mattias Svensson

In lung tissue, dendritic cells (DC) are found in close association with the epithelial cell layer, and there is evidence of DC regulation by the epithelium; that epithelial dysfunction leads to overzealous immune cell activation. However, dissecting basic mechanisms of DC interactions with epithelial cells in human tissue is difficult. Here, we describe a method to generate a three-dimensional...

Journal: :Journal of immunology 2005
Jianfei Yang Brian E Castle Adedayo Hanidu Lisa Stevens Yang Yu Xiang Li Carol Stearns Vladimir Papov Daniel Rajotte Jun Li

CD4+ Th1 cells produce IFN-gamma, TNF-alpha, and IL-2. These Th1 cytokines play critical roles in both protective immunity and inflammatory responses. In this study we report that sphingosine kinase 1 (SPHK1), but not SPHK2, is highly expressed in DO11.10 Th1 cells. The expression of SPHK1 in Th1 cells requires TCR signaling and new protein synthesis. SPHK1 phosphorylates sphingosine to form sp...

2017
Tsvetelina Batsalova Zhivka Kostova Dzhemal Moten Ivanka Teneva Balik Dzhambazov

Chemokines play a key role in the regulation of cell trafficking during immune responses. In pollen-allergic individuals, the roles of chemokines have been predominantly studied during active allergic reactions. However, little is known about chemokine levels and their effect on immune responses out of the pollen season when atopic individuals do not show clinical symptoms of allergy. Therefore...

2013
Gyeoung-Jin Kang Sang-Chul Han Jong-Woo Ock Hee-Kyoung Kang Eun-Sook Yoo

Citrus fruit contain various flavonoids that have multiple biological activities. However, the content of these flavonoids are changed during maturation and immature Citrus is known to contain larger amounts than mature. Chemokines are significant mediators for cell migration, while thymus and activation-regulated chemokine (TARC/CCL17) and macrophage-derived chemokine (MDC/CCL22) are well know...

Journal: :Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 2013

Journal: :Journal of immunology 2010
Bartosz Stolarski Mariola Kurowska-Stolarska Peter Kewin Damo Xu Foo Y Liew

IL-33 has emerged as an important mediator in the immunopathogenesis of allergy and asthma. However, the role of IL-33 in eosinophil-mediated inflammation has not been fully explored. In this article, we report that IL-33 directly stimulates eosinophil differentiation from CD117(+) progenitors in an IL-5-dependent manner. Although resting eosinophils expressed moderate levels of the IL-33R alph...

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