A straightforward protocol was developed to produce rosemary particles using whey and soy protein carriers. The post-processing retention of carnosic acid (CA), carnosol (CR) rosmarinic (RA), their bioaccessibility, in vitro antioxidant activity, storage stability were investigated protein-rosemary compared extract (RME). Solids recovery highest for or whey-inulin blend complexed with (R–WPI, R...

Abstract Rosemary Oil ( Rosmarinus officinalis ) contains carnosic acid, carnosol, and rosmarinic which are sources of active antioxidants. The Secretome MSC has growth factors such as antioxidants that protect HDFs. This study aimed to obtain a gel formulation from secretome combinates with test its effect an antioxidant. antioxidant, propylene glycol humectants, Carbomer 940 gelling agent, tr...

The anticarcinogenic effect of rosemary has been partly attributed to the modulation of the activity and expression of phase II detoxification enzymes. Here we compared the effects of phenolic diterpenes from rosemary on the expression of NAD(P)H: quinone oxidoreductase 1 (NQO1) in rat Clone 9 liver cells. Cells were treated with 1-20 μmol/L of carnosic acid (CA) or carnosol (CS) for 24 h. Both...

Rosmarinus officinalis L. is commonly used as a spice and flavoring agent. Diterpenes are the main active compounds of R. officinalis. An Ultra High Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-ESI-MS/MS) method was developed for the determination of carnosol, rosmanol, and carnosic acid isolated from R. officinalis in rat plasma, and applied to a pharmacokinetic study afte...

Oxidative stress has been implicated as a contributing factor to neurodegeneration in Alzheimer's disease. An endogenous, low molecular weight (LMW) inhibitor from Alzheimer's brain inactivates the human brain muscarinic acetylcholine receptor (mAChR). The inhibitor prevents agonist and antagonist binding to the mAChR as assessed by radioligand binding studies. The LMW endogenous inhibitor, whi...

Natural products including phytochemicals have been recently proposed as tumor suppressors. In this paper, docking study is presented to use these phytochemicals for their prospective role in cancers including breast and prostate cancer. The most common type of cancer in women all over the world is breast cancer. The breast cells including cancerous breast cells have receptors for binding with ...

In our previous studies, we have reported that carnosic acid (CA) and carnosol (CS) originating from rosemary protects cortical neurons by inducing phase 2 enzymes, the induction of which was initiated by activation of the Keap1/Nrf2 pathway , , . In the present study we address the nature of the effector of these neuroprotective effects downstream of the phase 2 enzyme induction. From our resu...

Colorectal and pancreatic cancers remain important contributors to cancer mortality burden and, therefore, new therapeutic approaches are urgently needed. Rosemary (Rosmarinus officinalis L.) extracts and its components have been reported as natural potent antiproliferative agents against cancer cells. However, to potentially apply rosemary as a complementary approach for cancer therapy, additi...