introduction demyelination is a common lesion of spinal cord injury; cell therapy is an approach for replacing the lost oligodendrocytes. objective in this study, bone marrow stromal cells (bmscs) have been transdifferentiated into oligodendrocyte-like cells (olcs) and used in cytotherapy of contused spinal cords in rats. materials and methods the bmscs were collected from rat long bones, cultu...

objective(s): intracerebral injection of bone marrow stromal cells (bmscs) is being investigated as a therapeutic tool to prevent alzheimer's disease (ad). our aim was to investigate the effects of bmscs by intrathecal injection in ad rat model. materials and methods: bmscs were obtained from the bone marrow of wistar rat and transplanted into ad rat model via intrathecal injection. the ra...

objective(s): bone marrow-derived mesenchymal stem cells (bm-mscs) potentials make them appropriate for cell therapy including ability of differentiation and release of anti-inflammatory cytokines and growth factors secreta. for treatment of azoospermia to induce proliferation and differentiation of germ cells, mscs transplantation has been introduced. the aim of the present experimental case-c...

how to cite this article: taghdiri mm. other experimental therapies in neimann pick diseases. iran j child neurol. 2015 autumn;9:4(suppl.1): 25.   pls see pdf.

objective: demyelination of cns axons occurs under pathological conditions such as multiple sclerosis and spinal cord injuries, but can be repaired by cell therapy. within the cns remyelination can be achieved by transplantation of neural stem cells (nscs). nscs are self-renewing cells that maintain the capacity to differentiate into cns-specific cell types and can differentiate into the three ...

background: in recent years we have successfully adopted an in vitro hepatogenic differentiation of mesenchymal stem cells (mscs). in this protocol the biologically active hepatocyte-like cells were differentiated from the stem cells isolated from either bone marrow or umbilical cord blood (ucb) samples. the aim of the present study was to compare the efficiency of the hepatogenic differentiati...

Abstract Background Bone marrow mesenchymal stem cells are a potential resource for the clinical therapy of certain diseases. Canine, as companion animal, living in same space with human, is an ideal new model human diseases research. Because high prevalence diabetes, alternative transplantation islets (i.e. insulin producing cells) diabetes treatment will be urgent need, which makes our resear...

Effectiveness of bone engineering by cell sheet technology to repair canine mandibular injuries was investigated. Cell sheets were produced from canine stem cells cultured by density gradient centrifugation and osteoblast induction. A scaffold surface of polylactic-co-glycolic acid (PLGA) copolymer was wrapped with cell sheets. Mandibular injuries were created in 12 healthy dogs followed by imp...

Visceral leishmaniasis (VL), also known as kala-azar, is a disseminated protozoan infection caused by Leishmania donovani complex. Traditionally the definite diagnosis is made by amastigote detection in the tissue. The aim this study was to evaluate the PCR technique in stained slides of bone marrow and lymph nodes aspirates with suspect diagnosis for leishmaniasis. Slides were selected totalin...

in order to study the normal hematopoiesis, cellular components and myeloid/erythroid (m/e) ratio in the bone marrow of the pheasant (phasianus colchicus), bone marrow samples were collected from the proximal tibiotarsus bone of 16 clinically healthy adult pheasant. the bone marrow smears were stained using the giemsa stain. the results indicated that the development and formation of blood cell...