Abstract: Introduction: Microsponges provides a proficient drug delivery system for specific in the upper gastrointestinal tract with high loading capability. But formulation is affected by numerous process and design related factors. The intention of current research work was to formulate optimize floating gastroretentive microsponges glipizide, an antidiabetic drug, minimum number experiments...

Mustard oil cake (Brassica napus), the residue obtained after extraction of mustard oil from mustard oil seeds, was investigated for the production of lipase under solid state fermentation (SSF) using the marine yeast Yarrowia lipolytica NCIM 3589. Process parameters such as incubation time, biomass concentration, initial moisture content, carbon source concentration and nitrogen source concent...

Cordycepin is one of the most important bioactive compounds produced by species of Cordyceps sensu lato, but it is hard to produce large amounts of this substance in industrial production. In this work, single factor design, Plackett-Burman design, and central composite design were employed to establish the key factors and identify optimal culture conditions which improved cordycepin production...

Box and Hunter (1961) made an important observation that any fractional factorial design of resolutionR has the property that when projected onto anyR 1 factors it becomes a full factorial design. This has a signi cant implication for statistical analysis. We observe that the Plackett-Burman and related designs have a hidden projection property with an analogous implication for the analysis. Be...

The nutritional medium requirement for alkaline protease production was optimized by newly isolated Bacillus amyloliquefaciens B7. The variables significantly influencing the protease activity were screened through one-factor-at-a-time experiments and Plackett–Burman design, by which fructose and yeast extract were identified as the most significant variables. The steepest ascent method was emp...

An active strain, isolated from soil of Chhattisgarh, India, showed broad-spectrum antimicrobial activity against various pathogenic bacteria and fungi in glucose soybean meal broth. Strain was characterized as Streptomyces hygroscopicus MTCC 4003 based on 16S rRNA sequencing from Microbial Type culture Collection (MTCC), IMTECH, Chandigarh, India. Identification of the purified antimicrobial c...

The Cr(VI) removal capability of Acinetobacter junii VITSUKMW2 isolated from the Sukinda chromite mine site was evaluated and enhanced using statistical design techniques. The removal capacity was evaluated at different pH values (5-11) and temperatures (30-40 degrees C) and with various carbon and nitrogen sources. Plackett- Burman design was used to select the operational parameters for biore...

The main objective of the study is to enhance the mevastatin production using Plackett-Burman (PB) and central composite design (CCD) by Aspergillus terreus in submerged fermentation (SmF). Eight nutrients were chosen for a PB design with 12 experimental runs. A maximum mevastatin production of 170.4 mg L-1 was obtained in PB design. Response surface methodology (RSM) is a sequential procedure ...