There is little knowledge on the morphology of the brain stem in survivors of head injury, as CT fails to shown brain stem lesions, and neuropathological data is only available from autopsies. As magnetic resonance imaging (MRI) sheds new light on morphological lesions of the brain, the authors investigated 100 patients with a severe head injury. MRI was performed in a prospective study within ...

Abstract Spinal cord injury (SCI) often causes severe and permanent disabilities due to the regenerative failure of severed axons. Here we report significant locomotor recovery both hindlimbs after a complete spinal crush. This is achieved by unilateral transduction cortical motoneurons with an AAV expressing hyper-IL-6 (hIL-6), potent designer cytokine stimulating JAK/STAT3 signaling axon rege...

Stem cell therapy for adult stroke has reached limited clinical trials. Here, we provide translational research guidance on stem cell therapy for neonatal hypoxic-ischemic brain injury requiring a careful consideration of clinically relevant animal models, feasible stem cell sources, and validated safety and efficacy endpoint assays, as well as a general understanding of modes of action of this...

in the last few years, a lot of preclinical studies showed the therapeutic potential of stem cells in spinal cord injury (sci). neural stem cells (nscs) can be differentiated into all cell types of spinal cord. nscs are cells that maintain the capacity to differentiate into brain-specific cell types, and may also replace or repair of injury in central nervous system. here in, we describe the ef...

Electrospinning In article 2202785 by Liang Chen, Wenguo Cui, Yong Gu, and co-workers, a living-oriented fiber scaffold is found to fully exploit the advantage of stem cells, which can respond not only regulate local inflammatory microenvironment at early stages spinal cord injury, but also further differentiation fate continuously release brain-derived neurotrophic factor, promote neuronal reg...

A full description of brain-stem injuries should include their mechanisms and types of damage, distinguishing those which are primary and occur at the time of the injury, from those which are secondary and result from changes elsewhere in the brain or in other parts of the body; and the various lesions should be related to the clinical condition of the patients. Unfortunately, knowledge is insu...

introduction: in iran, thousands of young individuals become victims of head injury annually. head injury can damage neuronal cells which may in turn complicate the recovery of the patients. also, the increase of iron in cerebrospinal fluid (csf) following head injury may contribute to the hypoxic-ischemia brain damage by catalyzing the formation of free radicals (harber-weiss rection). the obj...

over half of all reported traumatic brain injuries are the result of a motor vehicle accident. other then the direct head impact itself, the sheer forces of the accident can cause the brain also to collide against the internal bone of the skull. in fact, when a moving head comes to a quick stop, the brain continues in its movement, striking the interior of the skull. this can cause bruising of ...

in recent years, the usefulness of intracranial pressure (icp) monitoring has been questioned in several reports for traumatic brain injury (tbi) management. therefore the needs of multidisciplinary groups of discussion of neurosurgeons and neurointensivists to update practical applications of icp in severe adult tbi has been advocated in many parts of the world. a consensus conference was held...

emotion regulation difficulties are from the factors that caused the incidents and automobile accidents and work related. this study aimed to comparing emotion regulation difficulties in mild traumatic brain injury (tbi) patients and normal people in kashan.the study was performed on 30 tbi patients referred to shahid beheshti hospital in kashan city and 30 normal people in kashan. tbi patients...