main goal in the management of patients with severe traumatic brain injury (tbi) is control of intracranial pressure (icp). decompressive craniectomy is an accepted technique for control of refractory intracranial hypertension in patients with severe tbi. because of high complication rate after decompressive craniectomy, new techniques such as basal cisternostomy have developed. we herein repor...

conclusions a long-term longitudinal study encompassing integrated research is needed to fully understand the traumatic experiences of caregivers. unless research on tbi or dai trauma is given its proper attention, the burden of trauma and injury on societies will continue to exacerbate globally. context as with care giving and rehabilitation in chronic illnesses, the concern with traumatic bra...

the serotonin (5-ht) receptors are a group of g protein-coupled receptors (gpcrs) and ligand-gated ion channels that found in the central and peripheral nervous systems. 5ht receptor can substantially influence brain functions such as learning and memory, perception of the environment, mood states, and responses to alcohol and other drugs of abuse. lysergic acid diethylamide (lsd) as a 5ht rece...

conclusions although ceiling effects should be considered for rehabilitation targets, the two-factor model of fim (motor and cognitive independence) has an eligible fitness for iranian patients with tbi. results the results of this study showed that the floor effect was not observed; however, ceiling effects were observed for the fim total score and its subscales. the confirmatory factor analys...

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Introduction: Brain injury is an important cause of morbidity and mortality worldwide and so far, there has been no absolute treatment for the damaged brain tissue. Using human stem cells with self-assembling scaffolds can be a promising method for treatment of traumatic brain injury. Materials and Methods: Human meningioma stem cells were isolated, cultured and then expanded into in vitro cond...

during the past two decades, a variety of serum or cerebrospinal fluid (csf) biochemical markers in daily clinical practice have been recommended to diagnose and monitor diverse diseases or pathologic situations. it will be essential to develop a panel of biomarkers, to be suitable for evaluation of treatment efficacy, representing distinct phases of injury and recovery and consider the tempora...

chiari malformation type i (cm-i) is a congenital disorder, which is basically a tonsillar herniation (≥ 5 mm) below the foramen magnum with or without syringomyelia. the real cause behind this malformation is still unknown. patients may remain asymptomatic until they engender a deteriorating situation, such as cervical trauma. the objective of this case report is to give a broad perspective on...

mycotic aneurysm of external carotid artery is extremely rare. we herein report a case of external carotid artery (eca) aneurysm following severe traumatic brain injury. a 24-year-old man with severe traumatic brain injury (tbi) following a car accident was referred to rajaee trauma center emergency room affiliated to shiraz university of medical sciences in shiraz, iran. he underwent ventricul...