PURPOSE To review clinical results of total knee arthroplasty (TKA) in rheumatoid arthritis (RA) patients with large bone defects of the tibial condyle. METHODS Records of 33 knees in 27 women and 3 men aged 44 to 80 (mean, 63.6) years who underwent primary TKA for RA with large tibial bone defects were reviewed. 16 knees had peripheral defects extending to the bone cortex, whereas 17 knees h...

PURPOSE The off-label use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for the treatment of mandibular bone defects was evaluated in 5 patients. The rhBMP-2 was used as an alternative to autogenous bone grafting. PATIENTS AND METHODS A total of 5 patients had mandibular defects reconstructed with rhBMP-2, 1.5 mg/mL, soaked collagen sponges alone or in combination with bone marr...

Background: Autogenous osteochondral grafting of articular defect in weight-bearing surface of large joints has proven to be a proper biomechanical and physiological solution for localized full-thickness defects.Objective: To study the gross and histopathological results of mosaicplasty in an animal model (sheep’s medial femoral condyle), evaluating the factors of defect and graft size, assessi...

background: autogenous osteochondral grafting of articular defect in weight-bearing surface of large joints has proven to be a proper biomechanical and physiological solution for localized full-thickness defects. objective: to study the gross and histopathological results of mosaicplasty in an animal model (sheep’s medial femoral condyle), evaluating the factors of defect and graft size, assess...

The healing of standardized bone defects grafted with either particulate ionomeric or hydroxyapatite bone substitutes was compared in the mandibular ramus of 30 Sprague-Dawley rats. The possible additional response achieved when combining these materials with a guided bone regeneration (GBR) technique was also evaluated. Three groups of 10 animals received either no implant material or ionomeri...

Background Cleft palate (CP) is a common congenital defect. It makes serious difficulties for cleft-affected children. The gold standard of care is autogenous bone grafting which may cause additional problems in donor site along with disappointing results. Tissue engineering is a promising solution for a widespread range of defects and disorders. It is reasonable to utilize this novel technolo...

introduction: bone regeneration grafts (brg) are widely used in the treatment of osseous defects and oral surgery. the various techniques and associated success rates of bone augmentation require evaluation by systematic review and meta-analysis of eligible studies. the aim of this systematic review was to compare alveolar bone regeneration in humans using bio-oss and autogenous bone graft. mat...

New strategies to fulfill craniofacial bone defects have gained attention in recent years due to the morbidity of autologous bone graft harvesting. We aimed to evaluate the in vivo efficacy of bone tissue engineering strategy using mesenchymal stem cells associated with two matrices (bovine bone mineral and α-tricalcium phosphate), compared to an autologous bone transfer. A total of 28 adult, m...

The effects of using a newly available water-soluble polymer bone hemostatic material in a contaminated environment were assessed in a rabbit tibial defect model. Infection rates and healing of polymer-treated bone were compared with the infection and healing of bone wax-treated bone and untreated controls after a bacterial challenge. Defects created in 24 rabbit tibias were treated with the po...