Scaffolds derived from decellularized tissues provide a natural microenvironment for cell culture. Embryonic cerebrospinal fluid (e-CSF) contains factors which play vital roles in development of the nervous system. This research was aimed to survey the effect of Wistar rat e-CSF on neural differentiation of bone marrow derived mesenchymal stem cells (BM-MSCs) cultured on the human amniotic memb...

In this paper we describe the development and content of Video-feedback Intervention to promote Positive Parenting for Children with Autism (VIPP-AUTI). VIPP-AUTI is an adapted version of the evidence-based intervention VIPP. The lack of social responsiveness in children with autism often lowers the quality of the parent-child interaction. A wide range of early interventions exist to cope with ...

Background: Skin flap procedures are employed in plastic surgery, but failure can lead to necrosis of the flap. Studies have used bone marrow mesenchymal stem cells (BM-MSCs) to improve flap viability. BM-MSCs and acellular amniotic membrane (AAM) have been introduced as alternatives. The objective of this study was to evaluate the effect of BM-MSCs and AAM on mast cells of random skin flaps (R...

Dear Editor CML and plasma cell myeloma (PCM) arise from pluripotent stem cells and lymphoid cells, respectively [1]. Since different cell lines give rise to CML and PCM, development of both malignancies in one patient is uncommon; only 17 such cases have been reported worldwide [2-5]. Here, we attempt to address questions about the mechanisms of co-existence of these two diseases. A 76-yr-old ...

introduction: the morphology and ultrastructure of germinal epithelum basement memberane (bm) in patients with non-obstructive azoospermia was studied by means of transmision electron microscipy. materials and methods: 10 biopsies of testis tissue from patients with non-obstructive azoospermia referred to royan institute as patients group and 5 biopsies from patients with prostatic cancer as co...

DNA-synthesis rates and concentrations of bone marrow (BM) and peripheral blood (PB) progenitor cells were studied in 22 patients treated with recombinant human interleukin-3 (rhIL3) as part of a clinical phase I/II study. Recombinant hIL3 at doses of 60 to 500 micrograms/m2 was administered by subcutaneous bolus injection for 15 days to 13 patients with solid tumors and preserved hematopoietic...

Abstract Acute Myeloid Leukemia (AML) is the abnormal differentiation of hematopoietic stem cells in bone marrow into malignant blasts. The leukemic environment plays an important role during disease progression, by shaping immune landscape interacting with these Mounting evidence suggests neutrophils are complicit within tumors enhancing tumorigenesis and immunosuppression; however, little kno...

Dear Editor, AML is a group of heterogeneous diseases derived from various cytogenetic and molecular abnormalities that are significant for diagnosis, treatment, and prognosis in many cases. We report a rare case of AML harboring t(11;19)(p15;p12) that was detected with whole-genome sequencing (WGS). A 33-yr-old woman was admitted to a local hospital with abdominal pain and diarrhea for five da...

In vitro growth and quantification of early (CD33–/CD38–) myeloid progenitor cells: stem cell factor requirement and effects of previous chemotherapy DARIO FERRERO, CRISTINA CHERASCO, BARBARA ORTOLANO, FULVIA GIARETTA, BENEDETTO BRUNO Divisione di Ematologia dell’Università di Torino, Azienda Ospedaliera "San Giovanni Battista", Turin, Italy Correspondence: Dario Ferrero, M.D., Divisione di Ema...

Increased marrow cellularity is well recognised in polycythaemia rubra vera (PRV), but its value in the differential diagnosis of polycythaemia is not always appreciated. In 28 patients who had marrow aspiration performed on account of a raised haemoglobin concentration or red blood cell count (RBC), marrow cellularity was assessed subjectively and also measured; a comparison was made with the ...