نتایج جستجو برای: bioactive motif
تعداد نتایج: 74879 فیلتر نتایج به سال:
Metalloproteases cleave proteins and peptides, and deregulation of their function leads to pathology. An understanding of their structure and mechanisms of action is necessary to the development of strategies for their regulation. Among metallopeptidases are the metzincins, which are mostly multidomain proteins with approximately 130-260-residue globular catalytic domains showing a common core ...
Lipoxygenases (LOX) contribute to vascular disease and inflammation through generation of bioactive lipids, including 12-hydro(pero)xyeicosatetraenoic acid (12-H(P)ETE). The physiological mechanisms that acutely control LOX product generation in mammalian cells are uncharacterized. Human platelets that contain a 12-LOX isoform (p12-LOX) were used to define pathways that activate H(P)ETE synthes...
Ginseng, which contains ginsenosides as bioactive compounds, has been regarded as an important traditional medicine for several millennia. However, the genetic background of ginseng remains poorly understood, partly because of the plant's large and complex genome composition. We report the entire genome sequence of Panax ginseng using next-generation sequencing. The 3.5-Gb nucleotide sequence c...
It is extremely difficult to realize two conflicting properties-high hardness and toughness-in one material. Nano-polycrystalline stishovite, recently synthesized from Earth-abundant silica glass, proved to be a super-hard, ultra-tough material, which could provide sustainable supply of high-performance ceramics. Our quantum molecular dynamics simulations show that stishovite amorphizes rapidly...
the cytotoxicity of the biomaterials is a key issue that should be addressed prior to pre-clinical applications. this study was designed to evaluate and compare the cytotoxixity of two forms of bioactive glasses:nanopowder:andmicropowder. human hgf1-pi53 gingival fibroblast cells were used to evaluate the cytotoxicity of 0.5, 1, 1.5, 2, 5, 10, 15 and 20 mg/ml concentrations of the two bioactive...
JASMONATE ZIM-domain (JAZ) proteins act as repressors of jasmonate (JA) signaling. Perception of bioactive JAs by the F-box protein CORONATINE INSENSITIVE1 (COI1) causes degradation of JAZs via the ubiquitin-proteasome pathway, which in turn activates the expression of genes involved in plant growth, development, and defense. JAZ proteins contain two highly conserved sequence regions: the Jas d...
In Iranian art, the horse is a solar symbol of the spiritual radiance of resurrection and life, and Muslims associate it with happiness and joy. With the development of pottery in the Seljuk period and with a brief look at the pottery left from this period, the horse motif has been depicted in abundance in the form of scenes such as riding, hunting, war, and literary themes. The artists were ab...
this study was carried out to investigate impacts of myrobalan rootstock and blackthorn interstem on fruit growth, physico-chemical features and bioactive compounds of two apricot cultivars (‘harcot’ and ‘roksana’) in 2010 and 2011. fruits of both cultivars on myrobalan and/or blackthorn grew with a classic double sigmoid curve from full bloom time to harvest. during growth and development peri...
conclusions increasing the cu nanoparticles in bioactive glass samples leads to the release of cu2+, which has a positive effect on the antibacterial mechanism, as well as decreasing the cultured staphylococcus colonies found on the bioglasses. therefore, it seems that the nanocomposite/bioglass of cuo is a promising option for aerobic bacterial inhibitor systems in common bone implant infectio...
TGF-beta is a potent stimulator of motility in a variety of cell types. It has recently been shown that hyaluronan (HA) can directly promote locomotion of cells through interaction with the HA receptor RHAMM. We have investigated the role of RHAMM and HA in TGF-beta-stimulated locomotion and show that TGF-beta triggers the transcription, synthesis and membrane expression of the RHAMM receptor a...
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