BACKGROUND Vessel dilator, a 37-amino acid peptide hormone synthesized in the heart, enhances urine flow 4- to 12-fold and sodium excretion 3- to 6-fold in healthy humans. The present investigation was designed to determine whether vessel dilator might have similar beneficial effects in persons with congestive heart failure (CHF). METHODS AND RESULTS Vessel dilator (100 ng/kg body weight per ...

OBJECTIVES The aim of the current study was to compare the objective and subjective effects of continuous positive airway pressure to the use of nasal dilator strips in patients with acromegaly and moderate to severe obstructive sleep apnea. METHODS We studied 12 patients with acromegaly and moderate to severe obstructive sleep apnea (male/ females = 8/4, age = 52 ± 8 ys, body mass index = 33...

The adrenergic receptors in man were analyzed using isolated sphincter, dilator, and ciliary muscle strips, dissected from eyebank eyes. The dilator is mainly alpha, the sphincter both alpha and beta, and the ciliary muscle predominantly beta adrenergic.

Femomi blood flow and arterial pressure l-esponses to stimulation of the lumbar sympathetic chain at L3, L4 and L5 were compared with i-esponses to intm-arterial injections of 1-epinephrine and 1-norepinephrine before and after progressively increasing levels of adrenergic blockade, and after atropine. The vasoconstrictor i-esponses to nerve stimulation resembled most closely those caused by 1-...

Dear Editor, We read with interest the recent article of Yavas on the tracheostomy in the intensive care unit.1 The authors treated 205 patients needing tracheostomy, 65.4% with surgical tracheostomy (ST) and 34.6% with percutaneous tracheostomy (PT). The authors, while performing PT, used two procedures: the Ciaglia percutaneous dilatational tracheostomy technique using multiple dilators and t...

The goal of this study was to compare the isolated and combined effects of two treatments being used to reduce nasal airflow resistance (NR): an internal nasal mechanical dilator (Nozovent; Prevancure; Sté Pouret, Paris, France) and a topical decongestant, fenoxazoline hydrochloride (Aturgyl; Synthelabo; Le Plessis-Robinson, France). The study was performed in 17 healthy subjects. NR was estima...

Endothelin has been characterized as a potent constricting factor. The purpose of this study was to investigate possible dilator effects of this peptide and to examine whether dilator responses occur through an endothelium-mediated mechanism in guinea pig coronary resistance vessels and isolated aortic rings. Changes in perfusion pressure after bolus injections of endothelin were measured using...