The title complex, [RhCl(C(21)H(21)O(3)P)(2)(CO)], is a rhodium analogue to Vaska's complex with para-meth-oxy substituents on the six phosphan-yl-aryl units. Two independent mol-ecules are present in the unit cell, with their metal atoms both located on an inversion centre. This causes the chloride and carbonyl ligands to exhibit a positional disorder in a 0.5:0.5 ratio. The two Rh(I) atoms ex...

Chlorpyrifos is one of the most popular pesticides used for agriculture crop protection, and widespread contamination is a potential concern. However, chlorpyrifos is hydrolyzed almost 1,000-fold slower than the preferred substrate, paraoxon, by organophosphorus hydrolase (OPH), an enzyme that can degrade a broad range of organophosphate pesticides. We have recently demonstrated that directed e...

The article by Jarvik et al, 1 appearing in this issue, illustrates the pros and cons of using a large panel of SNPs for probing deeper into the association between serum paraoxonase (PON1) and vascular disease. The obvious advantages of using such a series of convenient genetic markers are somewhat compromised in this instance by the presence of several, long-ago established recombination site...

Bifunctional fusion proteins consisting of organophosphate hydrolase (OPH) moieties linked to a Clostridium-derived cellulose-binding domain (CBD) were shown to be highly effective in degrading organophosphate nerve agents, enabling purification and immobilization onto different cellulose materials in essentially a single step. Enzyme kinetics studies were performed for the CBD-OPH fusions usin...

OBJECTIVE Paraoxonase (PON) is associated with high-density lipoprotein and protects serum lipid from oxidation. The aim of this study was to determine serum PON, arylesterase (ARE) activities, and total antioxidant capacity (TAC) in metabolic syndrome (MES). METHODS This case-control study was performed on 106 patients with MES and 231 healthy subjects. Serum PON and ARE activities were dete...

Oxidative chlorination with HCl/H2O2 in 1,1,1-trifluoroethanol was used to transform aryl iodides into aryliodine(III) dihalides. In this instance 1,1,1-trifluoroethanol is not only the reaction medium, but is also an activator of hydrogen peroxide for the oxidation of hydrochloric acid to molecular chlorine. Aryliodine(III) dichlorides were formed in 72-91% isolated yields in the reaction of a...

Employing (2-pyridyl)acetone as a new supporting ligand, the copper-catalyzed coupling reactions of aryl chlorides, aryl bromides, and aryl iodides with various phenols successfully proceeded in good yields under mild conditions. This reaction displays great functional groups compatibility and excellent reactive selectivity.

Organophosphorus (OP) pesticides can be rapidly detected by integrating organophosphorus hydrolase with an optical leaky waveguide biosensor. This enzyme catalyses the hydrolysis of a wide range of organophosphorus compounds causing an increase in the pH. Thus, the direct detection of OP is possible by monitoring of the pH changes associated with the enzyme's activity. This article describes th...

The 96 hrs LC50 values for malathion and glyphosate was determined to be 9.1 ppm and 5.5 ppb, respectively on the fairy shrimp, Streptocephalus dichotomus preadults. The 1/5 of 96 hrs LC50 of malathion (2.0 ppm) and glyphosate (1.1 ppb) respectively was chosen. The sub lethal toxic effect of each of these pesticides on the acetylcholinesterase activity (AchE) of S. dichotomus was assayed on day...

Novel aryl substituted pyrazaboles 2-9 with direct and acetylenic linkages were synthesized by Pd-catalyzed Suzuki or Sonogashira cross-coupling reactions. Their structural, thermal, and photonic properties were investigated. The results show that the aryl pyrazaboles 2-9 exhibit good thermal stability, high fluorescence quantum yield, and tunable photophysical properties. The aryl substituted ...