The purpose of treatment for uncomplicated malaria is to produce a radical cure using the combination of: artesunate (4 mg/kg/day) plus mefloquine (8 mg/kg day) for 3 days: a fixed dose of artemether and lumefantrine (20/120 mg tablet) named Coartem (4 tablets twice a day for three days for adults weighing more than 35 kg): quinine 10 mg/kg 8-hourly plus tetracycline 250 mg 6-hourly for 7 days ...

BACKGROUND The purpose of this study was to compare knowledge on the part of health workers in public and private health facilities about prescribing and dispensing of an artemether-lumefantrine combination, 3 years after moving from sulfadoxine-pyrimethamine to artemether-lumefantrine as a first-line treatment for nonsevere malaria in Tanzania. METHODS A cross-sectional survey of a convenien...

BACKGROUND The six-dose regimen of artemether-lumefantrine is effective and is among combination therapies prioritised to replace antimalarials that no longer work in Africa. However, its effectiveness has not been assessed in the field, and could be compromised by poor adherence, incorrect timing of doses, and insufficient intake of fatty foods with every dose. Our aim, therefore, was to asses...

We prospectively studied 803 Thai patients admitted to the Bangkok Hospital for Tropical Diseases to assess the safety, tolerability and effectiveness of treatments for strictly defined P. falciparum malaria. Patients were assigned to one of five treatment groups: (i) a 5-day course of intravenous artesunate in a total dose of 600 mg, Group Aiv; (ii) intravenous artesunate as in Group Aiv follo...

The objective of the present investigation was to develop a parenteral microemulsion delivering artemether, a hydrophobic antimalarial drug and to evaluate antimalarial activity of the microemulsion in comparison to the marketed oily injection of artemether (Larither(®)). The microemulsion was evaluated for various parameters such as globule size, ability to withstand centrifugation and freeze-...

The choice of appropriate artemisin-based combination therapy depends on several factors (cost, efficacy, safety, reinfection rate, and simplicity of administration). In this study, we tested the hypothesis that artesunate-mefloquine (Artequin) is as efficacious as artemether-lumefantrine (Coartem) in treatment of uncomplicated Plasmodium falciparum malaria. The study was carried out from Augus...

Progress has been made over the last decade with the development and clinical use of artemether as an agent against major human schistosome parasites. The tegument has been identified as a key target of artemether, implying detailed studies on ultrastructural damage induced by this compound. We performed a temporal examination, employing a transmission electron microscope to assess the pattern ...

Abstract: Objectives: Artemether (ART), an antimalarial drug, have poor solubility and low bioavailability. Therefore, solid dispersion of the drug was formulated using Soluplus (SOL) incorporated in fast disintegrating tablet. Materials Methods: The (SD) prepared solvent evaporation method a rotary evaporator. optimized SD evaluated then into Results: Solubility studies revealed that ART A3 ra...

Artemisinin is a good antimalarial drug independently developed in China. It highly effective and low toxic. In the process of studying mechanism artemisinin drugs, we found that there was agglutination when drugs came into contact with blood. Methods: ABO positive typing test card used to detect reaction dihydroartemisinic whole blood, red blood cells, hemolytic solution, hemin chloride, ferro...

A patient presenting with severe malaria, hyperparasitaemia, received 7-day artesunate monotherapy. recrudescence was detected and attributed to monotherapy a polyclonal infection without Kelch 13 gene mutation. second treatment artesunate, then quinine, followed by artemether-lumefantrine, successful.