background: â  advanced hepatic fibrosis and cirrhosis has generally been considered to be irreversible. the aim of this study was to determine whether cirrhosis is reversible.â  â  methods: â  seven patients with autoimmune hepatitis with histologic evidence of cirrhosis were enrolled. after treatment, they had follow-up liver biopsy while in clinical and biochemical remission. biopsy specimen...

Nature derived product drew a lot of interest because their potential nutritional and therapeutics value. Most natural compounds are now processed developed as possible antioxidative, antimitotic, antimicrobial, anti-inflammatory, antiangiogenic, anti-carcinogenic pharmaceutical agents. Indeed, several products have been used lead in the development most potent physiologically relevant chemical...

cutaneous leishmaniasis is a common tropical dermatose with diverse clinical presentations. at times, it may appear in unusual shape or unusual site that causes diagnostic challenge. we reported a case of unusual presentation of cutaneous leishmaniasis which appeared as an ulcer on the lower lip of a ten-year-old boy. the diagnosis was confirmed by identifying leishmania parasites at ulcer smea...

background management of bacterial sepsis as a common cause of hospitalization and a life threatening clinical syndrome is a challenge. in previous studies, incorrect diagnosis of sepsis and unnecessary treatment have been frequently reported. objectives the aim of this study was to evaluate the diagnosis and treatment of cases with a primary diagnosis of sepsis. patients and methods of 410 med...

patients presenting with nephrotic syndrome with or without nephritic illness rarely come across with the diagnosis of ‘c1q nephropathy’. this entity is purely diagnosed with the help of immunofluorescence like iga nephropathy. clinical presentation is heterogenous, ranging from nephrotic range proteinuria to sub-nephrotic state; and with or without hematuria / renal insufficiency. similarly, t...

Pathogenic bacteria resistant to many or all antibiotics already exist. With the decline in microbiological research at pharmaceutical companies, the high rate at which resistance has evolved and spread has demanded a novel approach to addressing this critical human health issue. In the present paper, we propose a new paradigm in antibiotic discovery and development, one that applies ecological...

The concept of 'obstetrical medicine' was established in the late 19th century, but overshadowed during most of the 20th century by dramatic improvements in surgical, anesthetic, antimicrobial therapeutics, and obstetrical methods and practice. During the last quarter of the 20th century the causes of maternal morbidity and mortality increasingly became pre-existing hereditable and acquired med...

Urinary tract infections (UTIs) are one of the most common bacterial infections, affecting 150 million people each year worldwide. High recurrence rates and increasing antimicrobial resistance among uropathogens are making it imperative to develop alternative strategies for the treatment and prevention of this common infection. In this Review, we discuss how understanding the: (i) molecular and...

Complex communities of bacteria, fungi, and viruses thrive on our skin. The composition of these communities depends on skin characteristics, such as sebaceous gland concentration, moisture content, and temperature, as well as on host genetics and exogenous environmental factors. Recent metagenomic studies have uncovered a surprising diversity within these ecosystems and have fostered a new vie...