Bacterial resistance to drugs is a global problem requiring the urgent development of new antibiotics. Antimicrobial peptides (AMPs) are excellent candidates for design novel antibiotics combat microbial resistance. In this research, we identified four (U-VVTX-Vp1a, U-VVTX-Vp1b, U-VVTX-Vp2a, and U-VVTX-Vp2b, respectively) from venom Vespa velutina, tested their antimicrobial, antioxidant, hemol...

Antimicrobial peptides represent one of the most promising future strategies for combating infections and microbial drug resistance. Tritrpticin is a 13mer tryptophan-rich cationic antimicrobial peptide with a broad spectrum of activity whose application in antimicrobial therapy has been hampered by ambiguity about its biological target and consequently the molecular interactions necessary for ...

BACKGROUND Antimicrobial peptides are a promising alternative to conventional antibiotics. Plants are an important source of such peptides; their pharmacological properties are known since antiquity. Access to relevant information, however, is not straightforward, as there are practically no major repositories of experimentally validated and/or predicted plant antimicrobial peptides. PhytAMP is...

the emergence of multi-drug resistant strains of pseudomonas aeruginosa has complicated treatment decision and may lead to treatment failures. in this study, we describe the trends of drug-resistant p. aeruginosa isolated in blood cultures from patients detected in a tertiary teaching hospital and evaluated the prevalence of resistance to amikacin, ampicillin, carbeni- cillin, cefixime, cefotax...

Urinary tract infections are one of the most common bacterial infections, especially in women and children, frequently treated with antibiotics. The alarming increase in antibiotic resistance is a global threat to future treatment of infections. Therefore, alternative strategies are urgently needed. The innate immune system plays a fundamental role in protecting the urinary tract from infection...

introduction: drug resistant staphylococci are the most important agents of nosocomial infections. in this survey, effect of different antibiotics on these bacteria and their drug resistance was investigated. methods: the study included 500 strains of staphylococci. minimum inhibitory concentrations of all antibiotics was determined by the broth macro dilution technique and standard methods fro...

There is a world-wide quest for development of new-generation antibiotics, due to the emergence of microbial pathogens that have developed resistance to the currently available antibiotics. The antimicrobial peptides (AMPs) are a strong candidate in this regard, due to minimal possibilities of emergence of resistance against these. The tryptophan (Trp)-rich peptides comprise an important class ...